You can not be too rich , too thin and have too low of an LDL famous quote from Dr Steve Nissen Of Clelveland Clinic a heavy weight in Preventive Cardiology Research !! very low levels of LDL were seen in Repatha FORUIER Trial with out any adverse outcomes over a period of time ! LDL hypothesis remains the cornerstone of CV prevention with the notion " lower the better" but still have to use the discretion which is that target population and by and large will be in Secondary Prevention with high risk for recurrence and progression of ASCVD

You can not be too rich , too thin and have too low of an LDL famous quote from Dr Steve Nissen Of Clelveland Clinic a heavy weight in Preventive Cardiology Research !! very low levels of LDL were seen in Repatha FORUIER Trial with out any adverse outcomes over a period of time ! LDL hypothesis remains the cornerstone of CV prevention with the notion " lower the better" but still have to use the discretion which is that target population and by and large will be in Secondary Prevention with high risk for recurrence and progression of ASCVD

Many high risk patients have goal<40

Thus far, there is no evidence establishing how low is too low. On the contrary, accumulating evidence suggests that achieving substantially lower levels than previously considered may be beneficial without causing harm.

Escalating therapy when statin alone fall shots allow us to confidently aim for intensive lipid targets without the lingering anxiety over cognitive or metabolic side effects

I believe that the closer we get to the target of 70, the better the outcomes.

Previously, there had been concerned about depression associated with very low LDL levels with this reassuringly has not proved to be the case.