Robustness of outcomes in trials evaluating sodium-glucose co‐transporter 2 inhibitors for heart failure
Source : https://onlinelibrary.wiley.com/doi/10.1002/ehf2.13785
Javed Butler , Corresponding Author Javed Butler Department of Medicine, University of Mississippi, Jackson, MS, USA Correspondence to: Javed Butler, Department of Medicine, University of Mississippi Medical Center, 2500 N...
Conclusion: Improvement in the composite outcome of first HF hospitalization or cardiovascular death was highly concordant and robust across sodium–glucose co-transporter 2 inhibitor trials. In contrast, secondary endpoints of all-cause and cardiovascular mortality were statistically fragile, underscoring the need to power trials for...
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Metabolic, structural and biochemical changes in diabetes and the development of heart failure - Diabetologia
Source : https://link.springer.com/article/10.1007/s00125-021-05637-7
Diabetes contributes to the development of heart failure through various metabolic, structural and biochemical changes. The presence of diabetes increases the risk for the development of cardiovascular disease (CVD), and...
Conclusion/Relevance: Lipotoxicity and glucotoxicity also contribute to impairments in vascular function, cardiac contractility, calcium signalling, oxidative stress, cardiac efficiency and lipoapoptosis. Lastly, changes in protein acetylation, protein methylation and DNA methylation contribute to a myriad of gene expression and protein...
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Empagliflozin Ameliorates Ouabain-Induced Na + and Ca 2+ Dysregulations in Ventricular Myocytes in an Na +-Dependent Manner - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34982348/
doi: 10.1007/s10557-021-07311-x. Online ahead of print. 1 Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. 2 National Clinical Research Center for Cardiovascular Diseases, Beijing, China. 3 Department...
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The year in cardiovascular medicine 2021: heart failure and cardiomyopathies - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34974611/
In the year 2021, the universal definition and classification of heart failure (HF) was published that defines HF as a clinical syndrome with symptoms and/or signs caused by a cardiac...
Conclusion: In patients hospitalized with COVID-19, acute HF and myocardial injury is quite frequent, whereas myocarditis and long-term damage to the heart are rather uncommon.
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Early Benefit with Empagliflozin in Heart Failure with Preserved Ejection Fraction Insights from the EMPEROR‐Preserved Trial
Source : https://onlinelibrary.wiley.com/doi/10.1002/ejhf.2420
Javed Butler , Corresponding Author Javed Butler Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, US Corresponding author. Javed Butler, MD MPH MBA. University of Mississippi Medical Center,...
Conclusion/Relevance: Our results reinforce the importance of early initiation of treatment in patients with HFpEF.
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