Hepatoprotective effects of gemigliptin and empagliflozin in a murine model of diet-induced non-alcoholic fatty liver disease - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34971904/
1 Department of Endocrinology and Metabolism, Ajou University School of Medicine, 164 Worldcup-ro, Yeoungtong-gu, Suwon, 16499, Republic of Korea. 2 Department of Physiology, Ajou University School of Medicine, 164 Worldcup-ro,...
Conclusion: These findings suggest that the GEMI, EMPA, and GEMI EMPA treatments ameliorate hepatic steatosis, inflammation, oxidative stress, and fibrosis in CDAHFD-induced NAFLD mouse models.
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Prognostic Value of Multiple Circulating Biomarkers for 2-Year Death in Acute Heart Failure With Preserved Ejection Fraction
Source : https://www.frontiersin.org/articles/10.3389/fcvm.2021.779282/full
Background: Heart failure with preserved ejection fraction (HFpEF) is increasingly recognized as a major global public health burden and lacks effective risk stratification. We aimed to assess a multi-biomarker model...
Conclusions: Multiple circulating biomarkers coupled with an appropriate machine-learning method could effectively predict the risk of long-term mortality in patients with acute HFpEF. It is a promising strategy for improving risk stratification in HFpEF.
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Rationale and design of the effects of EMpagliflozin on left ventricular DIAstolic function in diabetes (EmDia) study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34939776/
doi: 10.2459/JCM.0000000000001267. Online ahead of print. 1 Preventive Cardiology and Preventive Medicine, Department of Cardiology. 2 Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz....
Conclusion: By evaluating the short-term effect of empagliflozin with a comprehensive biobanking program, the EmDia Study offers an opportunity to primarily assess the effects on diastolic function but also to examine effects on clinical and molecular cardiovascular traits.
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Impact of Anemia and the Effect of Empagliflozin in HFrEF: findings from EMPEROR‐Reduced
Source : https://onlinelibrary.wiley.com/doi/10.1002/ejhf.2409
Corresponding Author João Pedro Ferreira MD, PhD Université de Lorraine, Inserm, Centre d'Investigations Cliniques Plurithématique 1433, and Inserm U1116, CHRU, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France Cardiovascular...
Conclusions: Anemia was associated with poor outcomes. Empagliflozin reduced new onset anemia throughout the follow-up and improved heart failure and kidney outcomes irrespective of anemia status at baseline.
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