Effect of Dapagliflozin Versus Empagliflozin on Cardiovascular Death in Patients with Heart Failure Across the Spectrum of Ejection Fraction: Cost per Outcome Analysis - American Journal of Cardiovascular Drugs
Source : https://link.springer.com/article/10.1007/s40256-023-00578-5
Background Dapagliflozin and empagliflozin have shown clinical benefits in patients with heart failure (HF). Their comparative monetary value remains undetermined, and we therefore sought to compare the cost-per-outcome implications of...
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Empagliflozin in heart failure with preserved ejection fraction with and without atrial fibrillation - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37062866/
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Tumor necrosis factor-α mediates inflammation-induced early-stage left ventricular systolic dysfunction
Source : https://journals.lww.com/cardiovascularpharm/Abstract/9900/Tumor_necrosis_factor___mediates.172.aspx
We have previously shown that rats with collagen-induced arthritis (CIA) have systemic inflammation, LV diastolic dysfunction, and that increased circulating TNF-α contributes to inflammation-induced HFpEF pathogenesis, but does not mediate...
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Use of Animal Models for Investigating Cardioprotective Roles of SGLT2 Inhibitors - Journal of Cardiovascular Translational Research
Source : https://link.springer.com/article/10.1007/s12265-023-10379-5
Sodium-glucose co-transporter 2 (SGLT2) inhibitors represent one type of new-generation type 2 diabetes (T2DM) drug treatment. The mechanism of action of an SGLT2 inhibitor (SGLT2i) in treating T2DM depends on...
Conclusions/Relevance: In this review, we summarize the animal models constructed to study the cardioprotective mechanisms of SGLT2is to help deliver a more comprehensive understanding of the in vivo work that has been done in this field and to help select the most optimal animal model to use when studying the different cardioprotective...
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Cardioprotective Effect of Empagliflozin and Circulating Ketone Bodies During Acute Myocardial Infarction - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37042253/
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Conclusions: One-week pretreatment with empagliflozin ameliorates ischemia reperfusion injury, reduces MI size and microvascular obstruction, increases myocardial salvage, preserves left ventricle systolic function, and lowers apoptosis and oxidative stress. Periprocedural intravenous infusion of BOHB during myocardial ischemia also induces...
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