Amyloid and collagen templates in aortic valve calcification
Source : https://pubmed.ncbi.nlm.nih.gov/38845326/
Calcific aortic valve disease (CAVD) is a widely prevalent heart disorder in need of pharmacological interventions. Calcified areas in aortic valves often contain amyloid fibrils that promote calcification in vitro....
Lipoprotein(a), a genetic risk factor for CAVD, augments calcification via several mechanisms, wherein hydrolysis of oxidized phospholipids (oxPLs) by Lp(a)-associated enzymes helps generate orthophosphate, and apolipoprotein(a) blocks plasmin-induced fibril degradation. Current studies of amyloid-calcium-collagen interactions in solution and...
Patients living with HIV infection had a higher risk of all-cause mortality, major adverse CV events, recurrent acute coronary syndromes, and admission for HF after the index event, despite being approximately 11 years younger at the time of the event.
Catheter ablation of atrial fibrillation compared with conventional medical therapies was associated with reduced risk of HF events in patients with reduced ejection fraction.
Physiology-guided complete revascularization effectively improved outcomes and decreased complication rate, irrespective of high bleeding risk status.
Ventricular tachycardia or ventricular fibrillation occurring ≥1 days after primary PCI and associated with cardiac arrest was rare, occurring in 0.4% of all patients and 0.1% of patients with uncomplicated STEMI.