Semaglutide and Diuretic Use in Obesity-Related Heart Failure With Preserved Ejection Fraction: a Pooled Analysis of the STEP-HFpEF and STEP-HFpEF-DM Trials
Source : https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehae322/7670783?login=false
AbstractBackground and Aims. In the STEP-HFpEF trial program, treatment with semaglutide resulted in multiple beneficial effects in patients with obesity-r
In obesity-related HF with preserved ejection fraction, semaglutide was effective in multiple domains, regardless of baseline diuretic use/dose, and let to a significant reduction in loop diuretic use over time.
The greatest reversals were seen in those aged <45 and 45-64 years, men, Non-Hispanic Black individuals, and those living in rural areas, the South, and the Midwest.
FFR-Guided Complete or Culprit-Only PCI in Patients with Myocardial Infarction
Source : https://pubmed.ncbi.nlm.nih.gov/38587995/
Among patients with STEMI or very-high-risk NSTEMI and multivessel coronary artery disease, FFR-guided complete revascularization was not shown to result in a lower risk of a composite of death from...
Fractional flow reserve–guided complete revascularization was not shown to result in a lower risk of a composite of death from any cause, MI, or unplanned revascularization than culprit-lesion-only PCI at 4.8 years.
Beta-Blockers After Myocardial Infarction and Preserved Ejection Fraction
Source : https://pubmed.ncbi.nlm.nih.gov/38587241/
Among patients with acute myocardial infarction who underwent early coronary angiography and had a preserved left ventricular ejection fraction (≥50%), long-term beta-blocker treatment did not lead to a lower risk...
Beta blockers did not lead to a lower cumulative incidence of the secondary endpoints (death from any cause, death from CV causes, MI, hospitalization for atrial fibrillation, and hospitalization for HF).
Causes and Clinical Outcomes of Patients Who Failed Screening for Transcatheter Tricuspid Valve Interventions
Source : https://pubmed.ncbi.nlm.nih.gov/38582312/
Transcatheter tricuspid valve intervention (TTVI) has recently emerged as a promising alternative to surgery for tricuspid regurgitation (TR). However, a significant proportion of patients fail screening for TTVI, and little...
The clinical outcomes of these patients who received optimized medical therapy alone were poor, with a 1-year composite of cardiac death or heart failure readmission of 47.4%.