Semaglutide in Patients With Obesity-Related Heart Failure and Type 2 Diabetes
Source : https://pubmed.ncbi.nlm.nih.gov/38587233/
Among patients with obesity-related heart failure with preserved ejection fraction and type 2 diabetes, semaglutide led to larger reductions in heart failure-related symptoms and physical limitations and greater weight loss...
Among patients with obesity-related HF with preserved ejection fraction and type 2 diabetes, semaglutide led to larger reductions in HF-related symptoms and physical limitations and greater weight loss than placebo at 1 year.
The models studied performed better than the measurement of N-terminal pro–brain natriuretic peptide level alone.
Left Ventricular Function, Congestion, and Effect of Empagliflozin on Heart Failure Risk After Myocardial Infarction
Source : https://pubmed.ncbi.nlm.nih.gov/38591260/
URL: https://www.clinicaltrials.gov; Unique identifier: NCT03496168.
Empagliflozin reduced the risk for first and total HF hospitalization, irrespective of LVEF or congestion or both.
Low Density Neutrophils and Neutrophil Extracellular Traps (NETs) Are New Inflammatory Players in Heart Failure
Source : https://pubmed.ncbi.nlm.nih.gov/38555028/
HFpEF patients present higher levels of circulating LDNs and NETs related activities, which are the highest in the context of acute HF decompensation.
Patients with HFpEF presented higher levels of circulating low-density neutrophils and neutrophil extracellular trap–related activities.
Sympathetic Neural Control at Rest and During the Cold Pressor Test in Patients With Heart Failure With Preserved Ejection Fraction
Source : https://pubmed.ncbi.nlm.nih.gov/38385250/
Despite augmented resting MSNA burst frequency, burst incidence was not significantly different between groups, and sympathetic baroreflex sensitivity was reduced in patients with HFpEF. Furthermore, patients had preserved sympathetic reactivity...
Despite augmented resting muscle sympathetic nerve activity burst frequency, burst incidence was not significantly different between groups, and sympathetic baroreflex sensitivity was reduced in patients with heart failure with preserved ejection fraction.