Engineering Probiotics for Diabetes Management: Advances, Challenges, and Future Directions in Translational Microbiology - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39493275/
Scholarly critiques have explored diverse methodologies of probiotic engineering, including physical alteration, bioenrichment, and genetic manipulation. These techniques augment the therapeutic potency of probiotics by ameliorating gut microbiota, fortifying the...
Engineered probiotics offer a promising diabetes treatment by enhancing gut health and metabolic regulation. This review explores their mechanisms, clinical efficacy, and potential advantages over traditional therapies.
Early Fasting Serum Glucose or Weight Reduction With Tirzepatide and Metabolic Outcomes in People With Type 2 Diabetes: A Post Hoc Analysis of the SURPASS Trials - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40100982/
Both early glucose and weight responses with tirzepatide were associated with better longer-term metabolic outcomes. Early response may be a good clinical indicator that could help inform treatment individualization to...
Early glycemic or weight response to tirzepatide predicts better long-term metabolic outcomes, including improved HbA1c, weight, blood pressure, and lipids, supporting individualized treatment strategies in type 2 diabetes.
Associations Between Diabetes Mellitus and Neurodegenerative Diseases - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39859258/
Diabetes mellitus (DM) and neurodegenerative diseases/disturbances are worldwide health problems. The most common chronic conditions diagnosed in persons 60 years and older are type 2 diabetes mellitus (T2DM) and cognitive...
Diabetes mellitus, especially T1DM and T2DM, is strongly linked to neurodegenerative diseases like AD, PD, HD, and ALS, possibly via insulin signaling disruptions, oxidative stress, and inflammation.
Neonatal diabetes mellitus around the world: Update 2024 - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39344692/
Neonatal diabetes mellitus (NDM), defined as diabetes with an onset during the first 6 months of life, is a rare form of monogenic diabetes. The initial publications on this condition...
Over 40 genes are now linked to neonatal diabetes mellitus, with recent discoveries expanding genetic and therapeutic insights through stem cell and CRISPR research into diverse disease mechanisms.
Vitamin D Supplementation: Shedding Light on the Role of the Sunshine Vitamin in the Prevention and Management of Type 2 Diabetes and Its Complications - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39519484/
As the incidence of type 2 diabetes mellitus (T2DM) continues to increase globally, researchers are keen to investigate various interventions to mitigate its impact. Among these, vitamin D supplementation has...
Vitamin D supplementation may enhance glycemic control in type 2 diabetes by reducing inflammation, oxidative stress, and modulating cytokine profiles, supporting its use alongside anti-diabetic medications for improved outcomes.