Protective Factors and the Pathogenesis of Complications in Diabetes - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37638875/
Chronic complications of diabetes are due to myriad disorders of numerous metabolic pathways that are responsible for most of the morbidity and mortality associated with the disease. Traditionally, diabetes complications...
This review proposes revising diabetes complication classification, emphasizing vascular, parenchymal, and hybrid origins. It highlights the importance of protective factors in modulating complications and outlines future research needs.
Post-trial monitoring of a randomised controlled trial of intensive glycaemic control in type 2 diabetes extended from 10 years to 24 years (UKPDS 91) - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38772405/
University of Oxford Nuffield Department of Population Health Pump Priming.
Early intensive glycaemic control with sulfonylurea, insulin, or metformin in type 2 diabetes significantly reduces long-term risks of death and myocardial infarction, with lasting benefits for up to 24 years.
Challenges and opportunities in the management of type 2 diabetes in patients with lower extremity peripheral artery disease: a tailored diagnosis and treatment review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38926722/
Lower extremity peripheral artery disease (PAD) often results from atherosclerosis, and is highly prevalent in patients with type 2 diabetes mellitus (T2DM). Individuals with T2DM exhibit a more severe manifestation...
This review explores optimal medical management of patients with type 2 diabetes and peripheral artery disease, emphasizing cardiovascular prevention, GLP-1 receptor agonists, and SGLT2 inhibitors, based on evidence from cardiovascular outcome trials.
Gut microbiota and therapy for obesity and type 2 diabetes - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38596222/
There has been a major increase in Type 2 diabetes and obesity in many countries, and this will lead to a global public health crisis, which not only impacts on...
The review explores gut microbiota's role in obesity and Type 2 diabetes, highlighting the impact of pharmacotherapy, bariatric surgery, and microbiota-based interventions for effective obesity management and prevention.
Type 2 diabetes mellitus and neurodegenerative disorders: The mitochondrial connection - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39357690/
The incidence of type 2 diabetes mellitus (T2DM) has increased in our society in recent decades as the population ages, and this trend is not expected to revert. This is...
This review explores the link between Type 2 diabetes mellitus (T2DM) and neurodegenerative diseases, focusing on mitochondrial dysfunction as a common molecular pathway, offering insights for potential therapeutic approaches to improve healthspan.