Glucagon-Like Peptide-1 Receptor Agonists Reverse Nerve Morphological Abnormalities in Diabetic Peripheral Neuropathy
Source : https://pubmed.ncbi.nlm.nih.gov/38189936/
This study demonstrates the efficacy of GLP-1 RAs in improving neuropathy outcomes, evidenced by improvements in mainly structural and morphological measures and supported by electrophysiological and clinical endpoints. Future studies,...
A 3-month follow-up study demonstrated further improvement in nerve size in 93% of participants, accompanied by reduced severity of neuropathy.
Association of HbA1c Variability With Vibrating Perception Threshold in Middle-Aged and Elderly Patients With Type 2 Diabetes Mellitus: a Retrospective Cohort Study
To investigate the relationship between HbA1c variability and vibrating perception threshold in middle-aged and elderly patients with type 2 diabetes mellitus.
The risk of developing vibration sensation deficiency increases proportionally with higher glycated hemoglobin-CV levels in middle-aged and elderly patients with T2DM.
Metabolic Dysfunction-Associated Fatty Liver Disease in the Elderly With Diabetic Foot Ulcers: a Longitudinal Cohort Study
Source : https://pubmed.ncbi.nlm.nih.gov/38102851/
This study aimed to explore the association between metabolic-associated fatty liver disease (MAFLD) and ulcer recurrence risk in patients with diabetic foot ulcers (DFUs) through an ambispective longitudinal cohort.
After a median follow-up period of 36 months, patients with metabolic dysfunction-associated fatty livery disease (MAFLD) had a higher ulcer recurrence rate than patients without MAFLD.
A Transcriptome Array-Based Approach to Link SGLT-2 and Intrarenal Complement C5 Synthesis in Diabetic Nephropathy
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10707485/
Diabetic nephropathy is a common microvascular complication of diabetes mellitus. It is characterized by progressive chronic kidney disease (CKD) with decline of kidney function by hyperfiltration. On a mechanistic level,...
SGLT-2 inhibition exerts unequivocal nephroprotective effects by reducing glomerular hyperfiltration and albuminuria, tubular injury, loss of kidney function, and incidence of acute kidney injury.
Effect of Antidiabetic Drugs on Bone Health in Patients With Normal Renal Function and in Chronic Kidney Disease (CKD): Insight Into Clinical Challenges in the Treatment of Type 2 Diabetes
Source : https://www.mdpi.com/2077-0383/12/23/7260
Among the metabolic changes occurring during the course of type 2 diabetes (T2DM) and diabetic kidney disease (DKD), impaired bone health with consequent increased fracture risk is one of the...
Evidence from meta-analyses suggest potential positive effects on fracture risk by metformin and glucagon-like peptide 1 receptor agonists, neutral effects by dipeptidyl peptidase 4 inhibitors, sodium-glucose cotransporter 2 inhibitors, and sulfonylureas, but negative effects by insulin and thiazolidinediones.