Adverse drug reactions of GLP-1 agonists: A systematic review of case reports
Source : https://www.sciencedirect.com/science/article/abs/pii/S1871402122000418?via=ihub
GLP-1 receptor agonists are most commonly associated with gastrointestinal problems, particularly pancreatitis. * Exenatide and liraglutide caused maximum ADRs, whereas albiglutide and lixisenatide caused minimum ADRs. * Renal, dermatologic, hematologic,...
Conclusion: Gastrointestinal problems, particularly pancreatitis was the more frequently reported adverse drug reaction associated with GLP-1 agonist. The most adverse drug reactions were observed with liraglutide and exenatide.
New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35226299/
Obesity is an important risk factor of type 2 diabetes (T2D), which has become an important factor threatening human health. However, no perfect drug choice for obesity exists. Semaglutide is...
Relevance: This review summarizes clinical evidence of the semaglutide effect on T2D and obesity and establishes expectations on future clinical trials for obesity treatment.
Peptide-based long-acting co-agonists of GLP-1 and cholecystokinin 1 receptors as novel anti-diabesity agents
Source : https://www.sciencedirect.com/science/article/abs/pii/S0223523422001167?via=ihub
Novel GLP-1R/CCK-1R co-agonists derivatized from the peptide backbone of xGLP-1. * 2a and 2c exhibited potent and selective GLP-1R and CCK-1R activation potency. * 2a and 2c showed prominent hypoglycemic...
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Conclusion: These preclinical studies suggest that the pharmacological effects of CCK-1 and GLP-1 pathways can be harnessed in a single fusion peptide, yielding a promising combination therapy strategy for treating metabolic disorders.
The acceptability and effect of a culturally-tailored dance intervention to promote physical activity in women of South Asian origin at risk of diabetes in the Netherlands-A mixed-methods feasibility study
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0264191
Objective Populations of South Asian (SA) origin are at high risk of type 2 diabetes (T2D) and related complications. Analysis of T2D prevention interventions for these populations show that limited...
Conclusions: Bollywood Dance appears to be a feasible, culturally acceptable and potentially effective approach to increase PA in SA women in the Netherlands. A pilot cluster RCT is needed to confirm these initial findings on effectiveness.
Effect of glucagon-like peptide-1 receptor agonists on body weight in adults with obesity without diabetes mellitus-a systematic review and meta-analysis of randomized control trials - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35194917/
Clinical trials have investigated the weight loss effect of glucagon-like peptide-1 receptor agonists (GLP-1 RA) in adults with obesity without diabetes mellitus, but results for weight loss efficacy were varied....
Conclusion: The overall analysis results showed that GLP-1 RA improved glycemic control without increasing the risk of hypoglycemic events. Better control of blood pressure and plasma levels of LDL, HDL, and triglycerides was seen with GLP-1 RA treatment. Subgroup analysis showed greater treatment effect of semaglutide than liraglutide....