The Type 2 Diabetes Factor Methylglyoxal Mediates Axon Initial Segment Shortening and Alters Neuronal Function at the Cellular and Network Levels
Source : https://www.eneuro.org/content/8/5/ENEURO.0201-21.2021
Recent evidence suggests that alteration of axon initial segment (AIS) geometry (i.e., length or location along the axon) contributes to CNS dysfunction in neurological diseases. For example, AIS length is...
"Significance Statement- Small changes in the structure of the axon initial segment (AIS) affect neuronal function and may be a key mediator of neurological complications in various disease states. However, the specific disease factors that mediate structural changes at the AIS are relatively unknown. This is the first study to show that...
Genome-wide association analyses highlight etiological differences underlying newly defined subtypes of diabetes - Nature Genetics
Source : https://www.nature.com/articles/s41588-021-00948-2
Type 2 diabetes has been reproducibly clustered into five subtypes with different disease progression and risk of complications; however, etiological differences are unknown. We used genome-wide association and genetic risk...
We show that subtypes differ with regard to family history of diabetes and association with GRS for diabetes-related traits. The severe insulin-resistant subtype was uniquely associated with GRS for fasting insulin but not with variants in the TCF7L2 locus or GRS reflecting insulin secretion. Further, an SNP (rs10824307) near LRMDA was...
Highlights:
- People with type 2 diabetes have high risks of all-cause mortality and vascular complications.
- Compared to those with late-onset diabetes (disease onset after 60 years of age), persons with young-onset (disease onset before 40) and early-onset (disease onset between 40 and 60) type 2 diabetes are associated with further excess...
Low-grade inflammation as a risk factor for cardiovascular events and all-cause mortality in patients with type 2 diabetes - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34753497/
Low grade inflammation, as measured by hs-CRP, is an independent risk factor for vascular- and all-cause mortality but not for cardiovascular events in high-risk type 2 diabetes patients. Chronic low-grade...
Conclusion: Low grade inflammation, as measured by hs-CRP, is an independent risk factor for vascular- and all-cause mortality but not for cardiovascular events in high-risk type 2 diabetes patients. Chronic low-grade inflammation may be a treatment target to lower residual cardiovascular risk in type 2 diabetes patients.
Association between SGLT2 Inhibitors vs DPP-4 Inhibitors and Risk of Pneumonia Among Patients with Type 2 Diabetes
Source : https://doi.org/10.1210/clinem/dgab818
You do not currently have access to this article. Subscription prices and ordering for this journal Don't already have an Oxford Academic account? Register Association between SGLT2 Inhibitors vs DPP-4...
Conclusion: Compared to DPP4is, SGLT2is use was associated with a reduced risk of pneumonia and pneumonia mortality in a real-world setting.