Low-grade inflammation as a risk factor for cardiovascular events and all-cause mortality in patients with type 2 diabetes - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34753497/
Low grade inflammation, as measured by hs-CRP, is an independent risk factor for vascular- and all-cause mortality but not for cardiovascular events in high-risk type 2 diabetes patients. Chronic low-grade...
Conclusion: Low grade inflammation, as measured by hs-CRP, is an independent risk factor for vascular- and all-cause mortality but not for cardiovascular events in high-risk type 2 diabetes patients. Chronic low-grade inflammation may be a treatment target to lower residual cardiovascular risk in type 2 diabetes patients.
Association between SGLT2 Inhibitors vs DPP-4 Inhibitors and Risk of Pneumonia Among Patients with Type 2 Diabetes
Source : https://doi.org/10.1210/clinem/dgab818
You do not currently have access to this article. Subscription prices and ordering for this journal Don't already have an Oxford Academic account? Register Association between SGLT2 Inhibitors vs DPP-4...
Conclusion: Compared to DPP4is, SGLT2is use was associated with a reduced risk of pneumonia and pneumonia mortality in a real-world setting.
Elevated circulating follistatin associates with an increased risk of type 2 diabetes - Nature Communications
Source : https://www.nature.com/articles/s41467-021-26536-w
Follistatin promotes in type 2 diabetes (T2D) pathogenesis in model animals and is elevated in patients with T2D. Here the authors report that plasma follistatin associates with increased risk of...
Our findings suggest that GCKR regulates follistatin secretion and that elevated circulating follistatin associates with an increased risk of T2D by inducing adipose tissue insulin resistance.
Clinical Implications of MiR128, Angiotensin I Converting Enzyme and Vascular Endothelial Growth Factor Gene Abnormalities and Their Association with T2D
Source : https://www.mdpi.com/1467-3045/43/3/130
Type 2 DM (T2D) results from the interaction of the genetic and environmental risk factors. Vascular endothelial growth factor (VEGF), angiotensin I-converting enzyme (ACE), and MicroRNAs (MiRNAs) are involved in...
We conclude that the VEGF (rs699947), VEGF I/D and Mir128a (rs11888095) are potential risk loci for T2D, and that the D allele of the ACE ID polymorphism may be protective against T2D. These results help in identification and stratification for the individuals that at risk for T2D. However, future well-designed studies in different populations...
The role of circulating galectin-1 in type 2 diabetes and chronic kidney disease: evidence from cross-sectional, longitudinal and Mendelian randomisation analyses - Diabetologia
Source : https://link.springer.com/article/10.1007/s00125-021-05594-1
Aims/hypothesis Galectin-1 modulates inflammation and angiogenesis, and cross-sectional studies indicate that galectin-1 may be a uniting factor between obesity, type 2 diabetes and kidney function. We examined whether circulating galectin-1...
Conclusions/Interpretation: The role of circulating galectin-1 in type 2 diabetes and chronic kidney disease: evidence from cross-sectional, longitudinal and Mendelian randomisation analyses
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Type 2 Diabetes Connect4yrKey Points • Source: Diabetologia • Conclusion/Relevance: “Galectin-1 is strongly associated with lower kidney function in cross-sectional analyses, and two-sample MR [Mendelian randomization] analyses suggest a causal protective effect on kidney function among individuals Show More