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Type 2 diabetes mellitus increases the risk of hepatic fibrosis in individuals with obesity and nonalcoholic fatty liver disease - PubMed

Type 2 diabetes mellitus increases the risk of hepatic fibrosis in individuals with obesity and nonalcoholic fatty liver disease - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34553836/

doi: 10.1002/oby.23263. Online ahead of print. 1 Division of Endocrinology, Diabetes and Metabolism, University of Florida, Gainesville, Florida, USA. 2 Global Medicines Development, AstraZeneca plc, Gaithersburg, Maryland, USA. 3 Real-World...

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Low physical activity is associated with impaired endothelial function in patients with type 2 diabetes and controls after 5 years of follow-up - BMC Endocrine Disorders

Low physical activity is associated with impaired endothelial function in patients with type 2 diabetes and controls after 5 years of follow-up - BMC Endocrine Disorders

Source : https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s12902-021-00857-9

Background The long-term association between physical activity and endothelial function has not previously been investigated in patients with type 2 diabetes. Therefore, we aimed to evaluate the relationship between physical...

Conclusions
Daytime physical activity is associated with endothelial function after 5 years of follow-up in patients with type 2 diabetes and controls.


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    daytime physical activity was significantly lower in patients with type 2 diabetes and associated with endothelial function after 5 years follow-up in both patients with type 2 diabetes and controls
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Risk stratification of cardiac arrhythmias and sudden cardiac death in type 2 diabetes mellitus patients receiving insulin therapy: A population-based cohort study - PubMed

Risk stratification of cardiac arrhythmias and sudden cardiac death in type 2 diabetes mellitus patients receiving insulin therapy: A population-based cohort study - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/34545599/

HbA1c and lipid variability were predictive of SCD. Therefore, poor glucose control and variability in lipid parameters in diabetic patients are associated with aborted or actual SCD. These observations suggest...

Conclusion: HbA1c and lipid variability were predictive of SCD. Therefore, poor glucose control and variability in lipid parameters in diabetic patients are associated with aborted or actual SCD. These observations suggest the need to re-evaluate the extent of glycemic control required for outcome optimization.

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    Key Points • Conclusion/Relevance: “Poor glucose control and variability in lipid parameters in diabetic patients are associated with SCD [sudden cardiac death]. These observations suggest the need to re-evaluate the extent of Show More
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Cardiovascular risk factors early in the course of treatment in people with type 2 diabetes without established cardiovascular disease: a population‐based observational retrospective cohort study

Cardiovascular risk factors early in the course of treatment in people with type 2 diabetes without established cardiovascular disease: a population‐based observational retrospective cohort study

Source : https://onlinelibrary.wiley.com/doi/10.1111/dme.14697?af=R

This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between...

Conclusions
These analyses provide important information to identify people who may benefit from primary prevention of cardiovascular disease. Modifiable cardiovascular risk factors should be controlled early in all individuals with type 2 diabetes (as well as in all individuals with cardiovascular disease).

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Signaling defects associated with insulin resistance in non-diabetic and diabetic individuals and modification by sex

Signaling defects associated with insulin resistance in non-diabetic and diabetic individuals and modification by sex

Source : https://www.jci.org/articles/view/151818

Insulin resistance is present in one-quarter of the general population, predisposing to a wide-range of diseases. Our aim was to identify cell-intrinsic determinants of insulin resistance in this population using...