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3yr
Sleep interventions for children with attention deficit hyperactivity disorder (ADHD): A systematic literature review

Sleep interventions for children with attention deficit hyperactivity disorder (ADHD): A systematic literature review

Source : https://www.sciencedirect.com/science/article/pii/S1389945722012709?via=ihub

Strict review methods to ensure high-quality evidence imply few included studies. * The evidence is uncertain for six of the seven review outcomes. * Reduced sleep disturbances from behavioral interventions...



Conclusions: This review identified few and heterogeneous studies. A moderate certainty of evidence for a moderate effect size was only obtained for sleep disturbances from the behavioral interventions. A low certainty of the evidence for a moderate effect size was found for the total sleep time from the pharmacological intervention using...

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3yr
Prodrug technology use in ADHD

Prodrugs are used to boost drug permeation; they work by boosting lipophilicity or water solubility. Adequate prodrugs demonstrate sufficient lipophilicity, sufficient solubility/stability in water, and conversion to the parent drug in the body, as well as being safe.

Prodrugs can improve the delivery of an active drug or decrease toxicity. They are inactive compounds that need in vivo conversion to release therapeutically active medications. Prodrugs can concentrate in cells and act specifically.

How familiar are you with prodrugs in the treatment of ADHD? What do you see as the potential benefits or challenges with prodrugs?

  • 3yr
    Possibility of less abuse than as compared to regular drug and with the added capabilities should benefit from the get to.
  • 3yr
    prodrugs can be helped offering more predictability with half life and tolerance along with reducing abuse potential. currently there are limited options for prodrugs, primarily vyvanse and mydayis main Show More

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3yr
Prodrug technology use in ADHD

Prodrugs are used to boost drug permeation; they work by boosting lipophilicity or water solubility. Adequate prodrugs demonstrate sufficient lipophilicity, sufficient solubility/stability in water, and conversion to the parent drug in the body, as well as being safe.



Prodrugs can improve the delivery of an active drug or decrease toxicity. They are inactive compounds that need in vivo conversion to release therapeutically active medications. Prodrugs can concentrate in cells and act specifically.



How familiar are you with prodrugs in the treatment of ADHD? What do you see as the potential benefits or challenges with prodrugs?


  • 3yr
    Possibility of less abuse than as compared to regular drug and with the added capabilities should benefit from the get to.
  • 3yr
    prodrugs can be helped offering more predictability with half life and tolerance along with reducing abuse potential. currently there are limited options for prodrugs, primarily vyvanse and mydayis main Show More

Show More Comments

  • Saved

3yr
Prodrug technology use in ADHD

Prodrugs are used to boost drug permeation; they work by boosting lipophilicity or water solubility. Adequate prodrugs demonstrate sufficient lipophilicity, sufficient solubility/stability in water, and conversion to the parent drug in the body, as well as being safe.



Prodrugs can improve the delivery of an active drug or decrease toxicity. They are inactive compounds that need in vivo conversion to release therapeutically active medications. Prodrugs can concentrate in cells and act specifically.



How familiar are you with prodrugs in the treatment of ADHD? What do you see as the potential benefits or challenges with prodrugs?


  • 3yr
    Possibility of less abuse than as compared to regular drug and with the added capabilities should benefit from the get to.
  • 3yr
    prodrugs can be helped offering more predictability with half life and tolerance along with reducing abuse potential. currently there are limited options for prodrugs, primarily vyvanse and mydayis main Show More

Show More Comments

  • Saved

3yr
Effects of COVID-19 Lockdowns on the Development of Educational, Social and Emotional Gaps among Children: A Retrospective Chart Review - PubMed

Effects of COVID-19 Lockdowns on the Development of Educational, Social and Emotional Gaps among Children: A Retrospective Chart Review - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/36573771/

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Conclusions: Many children developed educational, social, emotional, and behavioral gaps during LD, and they lost skills to deal with everyday problems due to social isolation. It is important to follow the long-term impact of the lockdowns and social isolation.