Fronto-Cerebellar Neurometabolite Alterations After Methylphenidate in Children and Adolescents With ADHD: A Proton Magnetic Resonance Spectroscopy Study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36635897/
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site. The site is secure....
Conclusion: These findings propose that methylphenidate-induced metabolite changes in the fronto-cerebellar circuit could be associated with improvement in cognitive/behavioral characteristics in ADHD. Also, results highlighted cerebellar engagement in ADHD pathophysiology.
The effects of first-dose methylphenidate on the neural signatures of visual selective attention in children with attention-deficit/hyperactivity disorder
Source : https://www.sciencedirect.com/science/article/abs/pii/S0301051122002241?via=ihub
Although methylphenidate (MPH) has been shown to significantly improve selective attention in children with attention-deficit/hyperactivity disorder (...
Conclusions/Relevance: These findings suggest that N2pc and P3 are closely related to the mechanism of MPH in the ADHD treatment.
Altered cortical gyrification, sulcal depth, and fractal dimension in the autism spectrum disorder comorbid attention-deficit/hyperactivity disorder than the autism spectrum disorder - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36608165/
Autism spectrum disorder (ASD) frequently occurs accompanied by attention-deficit/hyperactivity disorder (ADHD), which catches increasing attention. The comorbid diagnosis of ASD with ADHD (ASD + ADHD) is permitted in the fifth...
Conclusion: Overall, the present study contributes to the delineation of particular structural abnormalities in ASD ADHD than ASD-only, enriching the evidence of the combined phenotype of ASD ADHD.
Dental trauma in children and adolescents with attention-deficit/hyperactivity disorder: A systematic review and meta-analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36606334/
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site. The site is secure....
Conclusion: Children and adolescents with ADHD are more likely to have dental trauma than their non-ADHD peers. However, due to limitations in the design of the included studies, a causal relationship cannot be established.
ATP9A deficiency causes ADHD and aberrant endosomal recycling via modulating RAB5 and RAB11 activity - Molecular Psychiatry
Source : https://www.nature.com/articles/s41380-022-01940-w
ATP9A, a lipid flippase of the class II P4-ATPases, is involved in cellular vesicle trafficking. Its homozygous variants are linked to neurodevelopmental disorders in humans. However, its physiological function, the...
Conclusion: Overall, these data have revealed a previously unknown role for ATP9A in activating RAB5 and RAB11 to promote the endosomal recycling pathway in N2a cells and mouse brains. Deficiency or mutation of ATP9A leads to inactivation of RAB5 and RAB11, resulting in abnormal endosomal recycling in neural cells. This leads to synaptic...