Assessing machine learning for fair prediction of ADHD in school pupils using a retrospective cohort study of linked education and healthcare data - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36576182/
ML approaches using linked routinely collected education and health data offer accurate, low-cost and scalable prediction models of ADHD. These approaches could help identify areas of need and inform resource...
Conclusions: ML approaches using linked routinely collected education and health data offer accurate, low-cost and scalable prediction models of ADHD. These approaches could help identify areas of need and inform resource allocation. Introducing ‘fairness weighting’ attenuates some sociodemographic biases which would otherwise underestimate...
Conclusions: In the present study, we found that ADHD children had significantly higher DMP levels and lower methylation levels than control children. A negative association between urinary OP metabolites and PON1 promotor mean methylation levels was found. As shown in the results, the PON1 AA genotype (rs705379) and PON1 CC genotype...
Driving under the Influence of Amphetamine: Analytical Evaluation of Illegal or Prescription Drug Intake Using Chiral UHPLC-MS/MS - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36525524/
Differentiation between consumption of illegal and prescription drugs remains an important aspect in forensic toxicology. While illicit amphetamine is most often racemic, the medicinal drugs marketed in Denmark for the...
Conclusions: Differentiation between consumption of illegal and prescription drugs remains an important aspect in forensic toxicology. While illicit amphetamine is most often racemic, the medicinal drugs marketed in Denmark for the treatment of attention deficit hyperactivity disorder (ADHD) contains the pure (S)-enantiomer or a prodrug thereof....
TTLL11 gene is associated with sustained attention performance and brain networks: A genome-wide association study of a healthy Chinese sample - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36511133/
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Conclusions/Relevance: Expression database showed that expression of this gene is enriched in the brain and that the G allele is associated with lower expression level than the A allele. These results suggest that TTLL11 may play a major role in healthy individuals' attention performance and may also contribute to the etiology of ADHD.
Online Parent Training for The Initial Management of ADHD referrals (OPTIMA): the protocol for a randomised controlled trial of a digital parenting intervention implemented to support parents and children on a treatment waitlist - Trials
Source : https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-022-06952-z
Background Children referred for attention-deficit/hyperactivity disorder (ADHD) often present with a broader pattern of conduct problems including oppositionality and defiance. This combination can be extremely stressful to parents, lower parents'...
Discussion: Digital solutions, such as mobile phone apps, have potential for delivering psychological support for parents of children with clinical-level needs in a timely and inexpensive manner. This trial will provide data on the clinical and cost-effectiveness of the STEPS app, which could support the implementation of this scalable...