Conclusion: Compared to the reported indentation numbers of the skin, our results demonstrate higher indentation numbers, indicating lower vaginal tissue firmness than the skin. This is in line with our observation that vaginal tissue firmness—obtained with the Cutometer—was lower (higher Uf) than dermal tissue firmness described in the...

Conclusion: This systematic review does not support an association between endogenous DHEA/DHEAS and depression in postmenopausal women.

Conclusion: this research presents a novel case for rilmenidine to be considered a potential calorie restriction mimetic through its prolongevity and health preserving effects, increased stress resistance, and increased autophagy. Alongside being a clinically approved antihypertensive drug, rilmenidine improves plasma lipid and blood glucose in...

Discussion: It is evident that there are cases where HRT is being overprescribed; specifically, private providers being prescribed doses above the licence recommendations. This has been recognised as an issue by the BMS and is in the process of being addressed.

Conclusion: Results corroborate previous studies and indicate that, similar to young adult samples, dissatisfaction with body image is a core feature of ED pathology across the lifespan.

Conclusion: In a cohort of women who transitioned to menopause naturally, we found that earlier age at menopause is associated with a lower cognitive performance score. This association was further exacerbated and mediated, but not moderated by insomnia symptoms. Our findings support the potential mediating role of insomnia, as both a...

Conclusion: In response to the proposed research objectives, this study noted that approximately 45% of menopausal women experience different degrees of health anxiety. In addition, the results indicated that physical exercise, interpersonal competence, and emotional intelligence are important factors influencing health anxiety in menopausal...

Conclusion: During the menopausal transition, approximately 50% to 75% of women have vasomotor symptoms and GSM symptoms. Hormonal therapy with estrogen is the first-line therapy for bothersome vasomotor symptoms and GSM symptoms, but nonhormonal medications (such as paroxetine and venlafaxine) also can be effective. Hormone therapy is not...

Conclusion: While HT use is a consideration for a majority of symptomatic, healthy, and recently menopausal women, nonhormone options may be utilized for women with contraindications to HT use, or for those who prefer to avoid HT use for any reason. Emerging therapies may provide additional options for women with bothersome VMS.

Discussion: Most of the studies on vaginal laser therapy are small, many are observational, include only short-term follow-up, and, importantly, had no sham group. A 2022 systematic review and meta-analysis found no benefit associated with these devices over vaginal estrogen but concluded the quality of the evidence was very low or low. While...

Conclusion: Late–reproductive-stage women experience multiple symptoms often associated with menopause. A better understanding of symptoms experienced among Spanish-speaking women may lead to more personalized health care and facilitate anticipatory guidance about menopause.

Conclusion: Success rates were similarly high for absorbable and permanent suture after uterosacral ligament suspension, sacrospinous ligament suspension, and sacrocolpopexy, with medium-term follow-up.

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Discussion: We conducted qualitative interviews with 20 HCPs in a noninterventional, cross-sectional, observational study documenting HCPs' views and practices regarding prescription and nonprescription treatments for VMS related to menopause. The interviews were designed to inform data collection for a more extensive retrospective review of...

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Discussion: The current noninterventional, retrospective, observational cohort study aimed to identify and characterize the use of prescription and nonprescription therapies for VMS recorded by HCPs, bridge gaps in our knowledge of the treatment of VMS, and describe the broad spectrum of prescription and nonprescription therapies (including...

Conclusion: We demonstrate how cardiovascular risk factors and vascular function evolve during menopausal transition. Although menopause was not associated with vascular impairment, short-term improvement in vascular function was observed in those using menopausal hormonal therapy. Intermittent nocturnal hypoxemia, obesity and impaired glucose...

Conclusion: Qualitative studies that explored the lived experiences of postmenopausal women with osteoporosis can provide important insights into the impact of the disease on women’s lives and potential pathways for improving care and management.

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Conclusion: While an association between testosterone and depression in postmenopausal women is not supported by this systematic review, this remains an uncertain conclusion due to methodologic limitations of the available data. Large, studies of community-based samples employing validated instruments for depression, and precise measurement...

Discussion: VMS, particularly VMS occurring during sleep, were associated with greater WMHV. Identification of female-specific midlife markers of poor brain health later in life is critical to identify women who warrant early intervention and prevention. VMS have the potential to serve as female-specific midlife markers of brain health in...

Conclusion: Our cohort had reasonably good bone health despite years of HIV and TDF therapy, but we did observe a trend toward increased BMD with a switch from TDF to TAF. The perimenopausal period is an important time to assess reversible parameters affecting bone health.

Conclusion: Substantial and consistent placebo effects were observed in RCTs for VMS treatment. These data suggest a reduction of 5.44 times per day in frequency and 0.36 in severity might be observed as a placebo effect.