Early menopause increases cognitive decline risk; menopausal hormone therapy may reduce mild cognitive impairment and Alzheimer's risk. Multidisciplinary care is crucial for mental health in affected women.

Daily fezolinetant 30 and 45 mg were efficacious and well tolerated for treating moderate to severe VMS associated with menopause.

In summary, during the period of perimenopause and menopause, many lifestyle factors can reduce the risk of developing all the diseases (cardiovascular disease, insulin resistance, type 2 diabetes mellitus, osteoporosis, and tumors) and symptoms characteristic of this period.

Microbiota changes during menopause may influence various diseases, and while probiotics show potential benefits, further research is needed to confirm their therapeutic efficacy.

Understanding this complex interplay of obesity and menopause is important to providing the right advice/management. We review the current evidence on obesity and menopause, focusing on the implications of increased obesity during menopause, the impact of menopause on obesity, and the effect of available treatments on associated morbidities.

Uterine fibroids (UFs) are common and often asymptomatic. TVUS is the initial diagnostic choice for its sensitivity and accessibility. MRI complements TVUS, especially in complex cases. Emerging technologies like SIS, elastography, CEUS, and AI show promise in improving diagnostic accuracy and efficiency for UFs.

In a globalized world with diverse populations, understanding menopause across cultural backgrounds is crucial for effective healthcare strategies and prevention concepts tailored to each woman's needs.

Women of reproductive age undergoing chemotherapy are at risk of irreversible ovarian failure. Current methods of determining the ovarian reserve do not accurately predict the future reproductive potential of patients undergoing chemotherapy. Among the most ovotoxic cytostatics are alkylating agents, mainly cyclophosphamide, but the adverse...

Through our review of the literature, we have determined that UTROSCT is a rare neoplasm. In our opinion, its pathological diagnosis can be difficult for many reasons. First, the neoplasm is rare, and often the diagnosis must be made by an expert in the field. In addition, due to the many histological features that the lesion can show, many...

Both groups adhered to the SIOMMMS guidelines, participated in daily outdoor walking for 30 min, and demonstrated improved physical performance and quality of life. However, the experimental group, who received Kinect-based VRT in addition to walking, exhibited more substantial enhancements compared to the control group. The findings suggest...

A significant decrease in estrogen levels disrupts immune homeostasis, particularly the levels of the immune factors TNF-α, IL-1β, IL-4, IL-6, IL-10 and IL-18 through the ERα/ERβ/GPER-associated NLRP3/NF-κB signaling pathway, which involves many signaling molecules, such as TLR2, TLR4, P2X7R, SIRT1, CREB, MS-KIF18A, PI3K, AKT, Gs, cAMP,...

Compared to placebo, plasma and salivary nitrate and nitrite increased at 3H and 4WK POST following nitrate treatment (P < 0.01), suggesting a functioning nitrate-nitrite-NO pathway in the participants of this study. There were no differences between treatments in FBFACh and FBFGTN-area under the curve (AUC) ratios [AUC ratios...

Here, we show that PFOS can be a good predictor of coronary artery disease, while PFOA can be an intermediate predictor of coronary microvascular disease. We also found that the PFAS levels in our study are significantly associated with inflammation-related proteins. Our findings may provide new insight into the potential mechanisms...

Migraines and persistent VMS jointly associate with greater risk for CVD and stroke, although risk is attenuated with adjustment for traditional CVD risk factors.

Using a range of methodologies and extensive consideration of confounders, these studies have shown that frequent and/or persistent VMS are associated with adverse CVD risk factor profiles, poorer underlying peripheral vascular and cerebrovascular health, and elevated risk for clinical CVD events. Collectively, the SWAN and MsHeart/MsBrain...

The relationship between race/ethnicity and severity of menopause symptoms was not solely explained by differences in socioeconomic status but is itself an independent factor.

Although the loss of sex hormones (estrogen, progestogens, and androgens) due to natural or iatrogenic menopause can impact sexual function, checking hormone concentrations is not recommended and should not be used to guide treatment.

Foods rich in anthocyanin should be emphasized for females, especially those who are menopausal, which may be of potential significance in the prevention of hyperuricemia.

For any vasomotor symptom trajectories, chronic discrimination was associated with "continuously high" and "high pre-FMP-decline post-FMP" versus "FMP-onset low" trajectories.