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Nonhormonal Therapies for Menopausal Vasomotor Symptoms

Source : https://jamanetwork.com/journals/jama/article-abstract/2809765

This article describes the use of fezolinetant and neurokinin B antagonists as nonhormonal therapies for menopausal vasomotor symptoms.

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Insights Into the Genetics of Menopausal Vasomotor Symptoms: Genome-Wide Analyses of Routinely-Collected Primary Care Health Records

Insights Into the Genetics of Menopausal Vasomotor Symptoms: Genome-Wide Analyses of Routinely-Collected Primary Care Health Records

Source : https://bmcmedgenomics.biomedcentral.com/articles/10.1186/s12920-023-01658-w

Vasomotor symptoms (VMS) can often significantly impact women's quality of life at menopause. In vivo studies have shown that increased neurokinin B (NKB) / neurokinin 3 receptor (NK3R) signalling contributes...

In this large study of menopausal VMS derived from primary care health records, researchers demonstrated the potential of routine health care data for deriving phenotypes not available in self-reported study data.

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Veozah (Fezolinetant): a Promising Non‐Hormonal Treatment for Vasomotor Symptoms in Menopause

Veozah (Fezolinetant): a Promising Non‐Hormonal Treatment for Vasomotor Symptoms in Menopause

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551868/

Vasomotor symptoms (VMS) are a common and distressing experience during menopause, affecting a significant portion of women. Hormone therapy (HT) has been the traditional treatment, but its limitations and potential...

Fezolinetant is the first nonhormonal therapy that can cross the blood‐brain barrier to inhibit neurokinin B and alleviate hot flashes in the body. Furthermore, the oral availability of fezolinetant provides a convenient option for menopausal women seeking relief from vasomotor symptoms, contributing to their overall well‐being and...

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2yr
Effect of Resistance Training Volume on Body Adiposity, Metabolic Risk, and Inflammation in Postmenopausal and Older Females: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Effect of Resistance Training Volume on Body Adiposity, Metabolic Risk, and Inflammation in Postmenopausal and Older Females: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Source : https://www.sciencedirect.com/science/article/pii/S2095254623000972?via=ihub

This meta-analytical study explored the effects of resistance training (RT) volume on body adiposity, metabolic risk, and inflammation in postmenopausal women.

Compared with CG, HVRT protocols elicit greater improvements in metabolic risk and inflammation outcomes than LVRT in overweight/obese postmenopausal and older females.

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Treatment of Urge Incontinence in Postmenopausal Women: a Systematic Review

Treatment of Urge Incontinence in Postmenopausal Women: a Systematic Review

Source : https://www.pagepressjournals.org/index.php/aiua/article/view/11718

Urinary incontinence and other urinary symptoms tend to be frequent at menopause because of hormonal modifications and aging. Urinary symptoms are associated with the genitourinary syndrome of menopause which is...

At present, a combination of different treatments tailored to the characteristics of the individual patient can be suggested.

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A Systematic Review of Menopause Apps With an Emphasis on Osteoporosis

A Systematic Review of Menopause Apps With an Emphasis on Osteoporosis

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542256/

Menopause can significantly hasten bone loss. Mobile phones provide an efficient way to manage, track and understand menopause using apps. A previous review of menopause apps found numerous apps designed...

Existing menopause apps need more input from experts to improve the quality and functionality, using simple language. More emphasis on specific health problems during menopause, including osteoporosis, is required.

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Impact of Estrogens on Resting Energy Expenditure: a Systematic Review

Impact of Estrogens on Resting Energy Expenditure: a Systematic Review

Source : https://pubmed.ncbi.nlm.nih.gov/37544655/

The fear of weight gain is one of the main reasons for women not to initiate or to early discontinue hormonal contraception or menopausal hormone therapy. Resting energy expenditure is...

It should be emphasized that estrogens have an anorexigenic effect and thus prevent increased EI from compensating for increased REE. Together with this fact, our results suggest that the energy balance changes in a negative direction under the influence of estrogens. Thus, the widespread fear of weight gain solely as a result of taking HC or...

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Summary of the 2023 North American Menopause Society Annual Meeting

Hot flashes, the havoc they can wreak on quality of life, and new ways to extinguish these challenging vasomotor symptoms took center stage at the 2023 annual meeting of the North American Menopause Society.

With a theme of Midlife Women’s Health in the Era of Precision Medicine, the four-day meeting was held at the Marriott Downtown in Philadelphia from Sept. 27 to 30, 2023. It featured up-to-date clinical information on treatment and prevention strategies for perimenopausal, menopausal, and postmenopausal women.

Click above to find our post-conference wrap-up report.

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Unexpected Drug-Induced Liver Injury Associated With MenoFit: A Synbiotic Menopause Supplement

Unexpected Drug-Induced Liver Injury Associated With MenoFit: A Synbiotic Menopause Supplement

Source : https://journals.lww.com/acgcr/fulltext/2023/09000/unexpected_drug_induced_liver_injury_associated.19.aspx

h 1 week of jaundice and abnormal liver biochemical tests in the absence of other risk factors and negative comprehensive workup for known etiologies of liver disease....

In the case described, given the significant improvement in liver tests on discontinuing the supplement and initiating steroids, the diagnosis of DILI was established. However, given the lack of long-term follow-up and lack of demonstration of normalization of liver tests, a suspicion of chronic DILI could not be ruled out.

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Number of Vaginal Lactobacilli in Postmenopausal Women With Vaginal Atrophy Before and After Treatment With Erbium-YAG Laser: a Randomized Sham-Controlled Trial

Number of Vaginal Lactobacilli in Postmenopausal Women With Vaginal Atrophy Before and After Treatment With Erbium-YAG Laser: a Randomized Sham-Controlled Trial

Source : https://bmcwomenshealth.biomedcentral.com/articles/10.1186/s12905-023-02590-y

Primary objective To evaluate the effect of erbium-YAG laser on the number of vaginal lactobacilli in postmenopausal women. Secondary objectives To evaluate the effect of erbium-YAG laser on vaginal atrophy...

This study showed an improvement in vaginal lactobacilli grading after vaginal laser treatment. However, the difference in vaginal lactobacilli grading after treatment in both groups was not statistically significant.

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3yr
Coverage of the 2023 North American Menopause Society Annual Meeting

The theme of the 2023 annual meeting of the North American Menopause Society, “Midlife Women’s Health in the Era of Precision Medicine,” set the tone for innovation.

The four-day program, which is taking place at the Marriott Downtown in Philadelphia, brought together more than 1,400 people from all over the world to discuss the latest thinking on addressing the symptoms of menopause and preventing or treating the health risks associated with advancing age in postmenopausal women.

Click above for a summary of some presentations that caught our eye at the conference.

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3yr
Assessing Young Adults' Menopause Knowledge to Increase Understanding of Symptoms and Help Improve Quality of Life for Women Going Through Menopause: a Student Survey

Assessing Young Adults' Menopause Knowledge to Increase Understanding of Symptoms and Help Improve Quality of Life for Women Going Through Menopause: a Student Survey

Source : https://bmcwomenshealth.biomedcentral.com/articles/10.1186/s12905-023-02641-4

Background Due to menopause being a largely invisible and under-discussed topic in wider society, women often deal with menopause-related complications on their own.

Our findings provide evidence that young adults of both sexes have a general baseline knowledge of menopause and its symptoms and are open to learning strategies to help support menopausal women.

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3yr
Role of Estrogen in the Regulation of Central and Peripheral Energy Homeostasis: From a Menopausal Perspective

Role of Estrogen in the Regulation of Central and Peripheral Energy Homeostasis: From a Menopausal Perspective

Source : https://pubmed.ncbi.nlm.nih.gov/37719789/

Estrogen plays a prominent role in regulating and coordinating energy homeostasis throughout the growth, development, reproduction, and aging of women. Estrogen receptors (ERs) are widely expressed in the brain and...

Cessation of the ovarian function with declined circulating E2 level leads to widespread changes in glucose and lipid metabolism. The adaption of women to menopause is individualized. Initiation of MHT at an early stage of menopause may effectively enhance the metabolic rate, and attenuate the development of obesity, insulin resistance, type...

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3yr
Preview of the 2023 North American Menopause Society Annual Meeting

The North American Menopause Society (NAMS) will host its annual meeting at the Marriott Downtown in Philadelphia from Sept. 27 to 30, 2023. The theme of this year’s meeting is Midlife Women’s Health in the Era of Precision Medicine. A vast array of speakers will cover recent clinical research and other content related to menopause and midlife women’s health. 

We will be covering the event for you, so check your email for highlights and a wrap-up of the conference. Click above for an exclusive preview of the event.

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3yr
Injection Treatments for Vulvovaginal Atrophy of Menopause: A Systematic Review - Aesthetic Plastic Surgery

Injection Treatments for Vulvovaginal Atrophy of Menopause: A Systematic Review - Aesthetic Plastic Surgery

Source : https://link.springer.com/article/10.1007/s00266-023-03550-5

Background Injection treatments have been proposed as novel treatment options for Vulvovaginal Atrophy of Menopause (VVA) also known as Genitourinary Syndrome of Menopause (GSM). However, to date data about these...

Conclusion: All assessed injection treatments except for MFAT seem to lead to significant improvement in VVA symptoms on validated questionnaires. Further studies are necessary in the field.

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Progestogens for endometrial protection in combined menopausal hormone therapy: A systematic review

Progestogens for endometrial protection in combined menopausal hormone therapy: A systematic review

Source : https://www.sciencedirect.com/science/article/pii/S1521690X23000891?via=ihub

Menopausal women with an intact uterus choosing estrogens for menopausal symptom relief require a progestogen for endometrial protection. The aim of t...

Conclusion: most studies demonstrated endometrial protection for the progestogen dose and time period examined. However, study quality varied which should be taken into account when choosing a combined MHT, especially if off-label-use is chosen.

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Age at Menopause and the Risk of Stroke: Observational and Mendelian Randomization Analysis in 204 244 Postmenopausal Women - PubMed

Age at Menopause and the Risk of Stroke: Observational and Mendelian Randomization Analysis in 204 244 Postmenopausal Women - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/37681566/

Background Observational studies have shown that women with an early menopause are at higher risk of stroke compared with women with a later menopause. However, associations with stroke subtypes are...

Conclusion: In our study, earlier age at menopause was related to a higher risk of stroke. We found no statistically significant association between genetically proxied age at menopause and risk of stroke, suggesting no causal relationship.

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A 65-Year-Old Woman With No Menopause History: A Case Report

A 65-Year-Old Woman With No Menopause History: A Case Report

Source : https://www.cureus.com/articles/170878-a-65-year-old-woman-with-no-menopause-history-a-case-report

Menopause is a universal occurrence in a woman's life where menstruation ceases, with an average age of 51.4 years in the United States. Late-onset menopause is defined as menopause after...

Conclusion: Our case serves as an illustrative example that, when combined with existing literature, highlights the importance of considering a newer holistic approach for practitioners evaluating vaginal bleeding in the geriatric population.

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3yr
Association Between Insomnia, Stress Events, and Other Psychosocial Factors and Incident Atrial Fibrillation in Postmenopausal Women: Insights From the Women's Health Initiative - PubMed

Association Between Insomnia, Stress Events, and Other Psychosocial Factors and Incident Atrial Fibrillation in Postmenopausal Women: Insights From the Women's Health Initiative - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/37646212/

Background The association between psychosocial factors and atrial fibrillation (AF) is poorly understood. Methods and Results Postmenopausal women from the Women's Health Initiative were retrospectively analyzed to identify incident AF...

Conclusion: Among postmenopausal women, 2 clusters of psychosocial stressors were found to be significantly associated with incident AF. Further research is needed to validate these associations.

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Assessment of women's treatment preferences for vasomotor symptoms due to menopause - PubMed

Assessment of women's treatment preferences for vasomotor symptoms due to menopause - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/37650213/

Sleep improvement and reductions in VMS frequency/severity were the most important treatment attributes.

Conclusion: Sleep improvement and reductions in VMS frequency/severity were the most important treatment attributes.

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