Can precision medicine get us through menopause?
Source : https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00544-8/fulltext
Women spend up to three decades in the post-menopausal phase of life, which is often accompanied by a wide variety of life-disrupting symptoms, including vasomotor symptoms, sleep disturbances, cognitive decline,...
Discussion: Using the comprehensive broad database generated, statistical mediation analyses were performed to lend insight into mechanisms driving the observed changes. These analyses revealed some novel and potentially important associations between diet, gut microbial changes, and health indicators.
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Lactobacilli and Cytokine Modifications during Menopause and Their Relation to Vulvar and Vulvovaginal Disorders
Source : https://e-jmm.org/DOIx.php?id=10.6118/jmm.22001
Lactobacilli and Cytokine Modifications during Menopause and Their Relation to Vulvar and Vulvovaginal Disorders Kushal Gandhi,Nathan Joshua Manales,John Garza,Samuel David,Asley Sanchez, 1 1 1 3 1 and Gary Ventolini 1...
Conclusion: The levels of vaginal cytokine and Lactobacillus profile were significantly different between the pre-menopausal and post-menopausal groups.
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"Let's see what happens:"-Women's experiences of open-label placebo treatment for menopausal hot flushes in a randomized controlled trial
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0276499
Open-label (honestly prescribed) placebos are an ethical way to evoke placebo effects in patients. As part of a mixed-methods study, we conducted in-depth interviews with eight menopausal women who underwent...
Discussion: The patient interviews with menopausal women who benefitted from OLP treatment as part of an RCT indicate that placebos administered without deception and embedded in a clinical context can elicit salubrious benefits. Participants noted that they had an initially positive, curious, and “couldn’t hurt” attitude towards...
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Hormone replacement therapy prescribing in menopausal women in the UK: a descriptive study
Source : https://bjgpopen.org/content/early/2022/10/31/BJGPO.2022.0126
Background Recent studies on the prescribing of hormone replacement therapy (HRT) medicines to treat symptoms of menopause are lacking. Aim To describe the prescribing of HRT in a cohort of...
Conclusion: This study shows a steady increase in the number of women receiving their first prescription for HRT during the study period, which suggests regained acceptance of HRT medicines.
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Discussion: The current state of communications may increase inequities in residency application processes; differences between faculty communications for applicants from different racial and ethnic backgrounds are particularly concerning given that program directors are more likely to weigh communications from faculty in their decision-making.
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