Cohort profile: a prospective Australian cohort study of women's reproductive characteristics and risk of chronic disease from menarche to premenopause (M-PreM)
Source : https://bmjopen.bmj.com/content/12/10/e064333
Purpose Previous studies have identified associations between individual reproductive factors and chronic disease risk among postmenopausal women. However, few have investigated the association of different markers of reproductive function, their...
Conclusion: Compared with the participants who completed the self-assessment or did not participate in the M-PreM Study, in-clinic participants were more likely to be university educated and less likely to have three or more children, to ever have smoked or have a history of preterm birth. They also started having children at a later age....
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Assessment of menopausal symptoms with changing hormone milieus in different menopausal transitional stages
Source : https://www.tandfonline.com/doi/abs/10.1080/07399332.2022.2134390?src=&journalCode=uhcw20
Abstract The present cross-sectional study is an attempt to evaluate menopausal symptoms with changing hormone milieus among women of different menopausal transitional stages. Out of all the symptoms, sexual dysfunction...
Conclusion: The present cross-sectional study is an attempt to evaluate menopausal symptoms with changing hormone milieus among women of different menopausal transitional stages. Out of all the symptoms, sexual dysfunction was the most commonly occurring symptom. Results of the correspondence analysis exhibited a significant association of...
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State-of-the-art review of the clinical research on menopause and hormone replacement therapy association with Parkinson's disease: What meta-analysis studies cannot tell us
Source : https://www.frontiersin.org/articles/10.3389/fnagi.2022.971007/full
The menopause is a midlife endocrinological process that greatly affects women's central nervous system functions. Over the last 2 decades numerous clinical studies have addressed the influence of ovarian hormone...
Discussion: Several works support the hypothesis that menopause may constitute a triggering risk factor, which interaction with other risk factors and other possible pathological processes may modify the onset of PD.
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Association of adverse pregnancy outcomes and multiple gestation with natural menopause: A population-based cohort study
Source : https://www.maturitas.org/article/S0378-5122(22)00219-5/fulltext
Early menopause, the cessation of ovarian function before the age of 45 years, affects approximately 10 % of women [1]. Women who experience early menopause are at increased risk of a nonfatal...
Conclusion: In this large cohort study, several statistically significant associations between APOs and age at natural menopause were observed. A deeper understanding of the relationships among APOs, menopause, and CVD is needed to help identify people at higher risk for early menopause and later CVD.
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History of Previous Midlife Estradiol Treatment Permanently Alters Interactions of Brain Insulin-like Growth Factor-1 Signaling and Hippocampal Estrogen Synthesis to Enhance Cognitive Aging in a Rat Model of Menopause
Source : https://www.jneurosci.org/content/42/42/7969
Across species, including humans, elevated levels of brain estrogen receptor (ER) α are associated with enhanced cognitive aging, even in the absence of circulating estrogens. In rodents, short-term estrogen treatment,...
Conclusion: Results indicate that short-term estrogen treatment following midlife loss of ovarian function has long-lasting effects on hippocampal function and memory by dynamically regulating cellular mechanisms that promote activity of ERα in the absence of circulating estrogens. Findings demonstrate how changes in hippocampal ERα...
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