Pharmacologic Treatment of Obesity in Reproductive Aged Women - Current Obstetrics and Gynecology Reports
Source : https://link.springer.com/article/10.1007/s13669-023-00350-1
Purpose of Review This report will review existing literature on weight loss outcomes for various anti-obesity medications (AOMs) as well as their effects on human fertility, pregnancy, or breastfeeding. Recent...
Summary: As the prevalence of obesity rises, AOMs have proven to be effective tools for weight loss in the general adult population. When prescribing AOMs to reproductive-aged women, providers should consider both the cardiometabolic benefits of these medications and potential effects that AOMs might have on hormonal contraception, pregnancy,...
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Conclusions: This study demonstrates a significant and growing public interest in “Ozempic” and related GLP-1 agonists. As the use of GLP-1 agonists for weight loss becomes more prevalent, plastic surgeons, particularly in the aesthetic setting, must be prepared for the downstream implications. Increased awareness, understanding, and...
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Pharmaceutical Therapies for the Treatment of Obesity: A Network Meta-analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37400324/
According to the results of this NMA, semaglutide seems to be an effective treatment option for both men and women, whereas beloranib appears to be particularly effective for women with...
Implications: According to the results of this NMA, semaglutide seems to be an effective treatment option for both men and women, whereas beloranib appears to be particularly effective for women with obesity and overweight, but its production has been stopped since 2016 and is not available.
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Beyond Ozempic: brand-new obesity drugs will be cheaper and more effective
Source : https://www.nature.com/articles/d41586-023-02092-9
Hormone mimics offer advantages even beyond those of the potent weight-loss jabs on the market now. Hormone mimics offer advantages even beyond those of the potent weight-loss jabs on the...
Relevance: Two new drugs for treating obesity are on course to become available in the next few years — and they offer advantages beyond those of the highly effective blockbuster drugs already on the market. The first, called orforglipron, is easier to use and to produce, and it will probably be cheaper than existing treatments. The second,...
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The Role of GLP1-RAs in Direct Modulation of Lipid Metabolism in Hepatic Tissue as Determined Using In Vitro Models of NAFLD - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37367037/
Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have been shown to improve glucose and lipid homeostasis, promote weight loss, and reduce cardiovascular risk factors. They are a promising therapeutic option for...
Conclusions/Relevance: Most recent clinical trials have suggested the importance of early pharmacologic intervention with GLP-1RAs in alleviating and limiting NAFLD, as well as highlighting the relative scarcity of in vitro studies on semaglutide, indicating the need for further research. However, extra-hepatic factors contribute to the...
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