Administration errors of compounded semaglutide reported to a poison control center - case series - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37392810/
These three semaglutide cases highlight the potential for patient harm given current practices. Vials of compounded semaglutide do not employ safety features provided by pre-filled manufactured pens and allow for...
Objectives: We aim to increase pharmacists’ and regulatory agencies’ awareness of emerging issues regarding current practices of semaglutide use in the community which has led to increased reports of administration errors and adverse drug events to our regional poison control center.
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Conclusions/Relevance: This case highlights the need for access to affirming weight management services for TGD patients pursuing GAS and the role of antiobesity medications in reaching presurgical BMI targets. Further studies should evaluate the needs of TGD patients in weight loss interventions and the effects of weight loss and antiobesity...
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Interpretation: In adults with overweight or obesity without type 2 diabetes, oral semaglutide 50 mg once per day led to a superior and clinically meaningful decrease in bodyweight compared with placebo.
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Interpretation: In this phase 2 trial the novel, oral, non-peptide GLP-1 receptor agonist orforglipron at doses of 12 mg or greater showed significant reductions in HbA1c and bodyweight compared with placebo or dulaglutide. The adverse event profile was similar to other GLP-1 receptor agonists in similar stage of development. Orforglipron...
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Tirzepatide 10 and 15 mg compared with semaglutide 2.4 mg for the treatment of obesity: An indirect treatment comparison - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37344384/
Currently there are no direct comparisons of tirzepatide and semaglutide for weight management. Using the matching-adjusted indirect treatment comparison method to compare the efficacy of tirzepatide and semaglutide for chronic...
Conclusions: Currently there are no direct comparisons of tirzepatide and semaglutide for weight management. Using the matching-adjusted indirect treatment comparison method to compare the efficacy of tirzepatide and semaglutide for chronic weight management, this analysis showed greater weight loss with tirzepatide 10 and 15 mg versus...
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