Obesity's transgenerational inheritance, driven by epigenetic mechanisms from parental obesity, contributes to offspring's increased body weight and long-term cardiometabolic risks, offering insights for improved clinical management and prevention strategies.

Sarcopenic obesity and osteoporosis are interrelated through muscle-lipid metabolism and inflammation. Addressing both conditions requires exploring new therapeutic targets and combining exercise with diet for improved musculoskeletal health.

Spexin's role in regulating energy metabolism and homeostasis, through hypothalamic melanocortin pathways, highlights its potential as a therapeutic target for addressing obesity, insulin resistance, and type 2 diabetes.

Resistin and other adipokines play crucial roles in obesity-related tumor development, highlighting their potential as targets for novel anti-tumor strategies to limit tumor growth and manage obesity simultaneously.

In conclusion, breastfeeding significantly influences childhood obesity risk through genetic factors and epigenetic mechanisms, emphasizing its importance in public health strategies to mitigate obesity prevalence.

This systematic review and meta-analysis found a significant association between cellulitis and obesity, highlighting the importance of maintaining a healthy BMI in affected patients.

Sarcopenic obesity may increase risks for cognitive impairment, coronary artery disease, and dyslipidaemia, but evidence is mainly from cross-sectional studies; further research is needed for clear definitions and outcomes.

Fecal microbiota transplantation (FMT) significantly alters recipients' phage populations, increasing diversity and variability, and correlates with the engraftment of donor phages and improved microbial diversity.

Preeclampsia, affecting 5-8% of pregnancies, is linked to obesity. ASB4, an E3 ligase, exacerbates preeclampsia-like symptoms in obese mice, with ASB4 gene variants associated with obesity in humans.

Resistant starch supplementation promotes weight loss and improves insulin resistance in overweight individuals by modifying gut microbiota, with Bifidobacterium adolescentis playing a key role in these benefits.

Mitochondrial dysfunction and dysregulated mitophagy in obesity and diabetes contribute to heart disorders. Targeted mitophagy interventions may restore mitochondrial function and improve cellular health in these conditions.

The review explores BAT activation's potential for obesity treatment, evaluating pharmacological, hormonal, and environmental factors influencing BAT's role in energy expenditure and weight reduction in humans.

Obesity increases the risk of ventricular arrhythmias via IL-6 trans-signaling. Olamkicept, an IL-6 inhibitor, shows promise but its role in obesity-linked arrhythmias remains underexplored.

The 2024 AHA Statistical Update offers comprehensive global and local cardiovascular data, emphasizing health equity and addressing structural racism to improve outcomes and access to care for all populations.

Optimizing meal timing by aligning with circadian rhythms can enhance metabolic health and prevent obesity-related diseases. Future interventions should consider individual chronotype and external factors for effective lifestyle modifications.

Obesity is a chronic disease and major public health issue in Spain, significantly increasing risk for multiple chronic conditions and cancers, with weight loss improving health outcomes.

The article examines obesity, its causes, compulsive forms like food addiction, and explores pharmacological treatments, including a new anorectic, for managing compulsive obesity.

Obesity drives atrial fibrillation through multiple mechanisms, worsening outcomes and impacting treatment efficacy. Weight loss improves AF risk and recurrence, highlighting the need for personalized management strategies.