Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: The SURMOUNT-4 Randomized Clinical Trial
Source : https://pubmed.ncbi.nlm.nih.gov/38078870/
ClinicalTrials.gov Identifier: NCT04660643.
Continued tirzepatide treatment effectively maintains and enhances initial weight loss in individuals with obesity, while withdrawal leads to significant weight regain.
Obesity and Inflammatory Factors in the Progression of Early-Onset Colorectal Cancer
Source : https://pubmed.ncbi.nlm.nih.gov/38611081/
Metabolic dysfunction associated with obesity leads to a chronic pro-inflammatory state with systemic effects, including the alteration of macrophage metabolism. Tumor-associated macrophages have been linked to the formation of cancer...
Understanding how obesity-related hormones and inflammatory mechanisms contribute to early-onset colorectal cancer can help develop new therapeutic targets and highlight the potential protective role of chemo-preventative agents like aspirin.
Obesity and body mass index: Past and future considerations in osteoarthritis research
Source : https://pubmed.ncbi.nlm.nih.gov/38354848/
Obesity is an important topic for the osteoarthritis (OA) scientific community. However, the predominant use of body mass index (BMI) to define obesity in OA research is associated with uncertainties...
Future OA research should adopt alternative measures beyond BMI to accurately identify obesity, consider evolving obesity science, and minimize weight stigma to enhance health outcomes for those with or at risk for OA.
Therapeutic advances in obesity management: an overview of the therapeutic interventions
Source : https://pubmed.ncbi.nlm.nih.gov/38715796/
Obesity has become a global epidemic in the modern world, significantly impacting the global healthcare economy. Lifestyle interventions remain the primary approach to managing obesity, with medical therapy considered a...
The future of obesity management may hinge on personalized medicine, targeting specific components for novel therapeutic agents, while leveraging the efficacy of GLP-1 RAs and bariatric surgery for comprehensive treatment.
Obesity, heart failure with preserved ejection fraction, and the role of glucagon-like peptide-1 receptor agonists
Source : https://pubmed.ncbi.nlm.nih.gov/38093506/
Heart failure with preserved ejection fraction (HFpEF) has a high prevalence, affecting more than 50% of patients with heart failure. HFpEF is associated with multiple comorbidities, and obesity is one...
GLP-1 receptor agonists show promise for treating obese patients with HFpEF by promoting weight loss and improving metabolic function, but efficacy and safety must be confirmed through clinical trials.
Obesity-induced blood-brain barrier dysfunction: phenotypes and mechanisms
Source : https://pubmed.ncbi.nlm.nih.gov/38678254/
Obesity, a burgeoning global health issue, is increasingly recognized for its detrimental effects on the central nervous system, particularly concerning the integrity of the blood-brain barrier (BBB). This manuscript delves...
Obesity-induced BBB dysfunction is crucial for addressing neurodegenerative disease risks and developing targeted therapies, emphasizing the need for continued research in this critical area of neurological health.
Obesity and male fertility disorders
Source : https://pubmed.ncbi.nlm.nih.gov/38593513/
Often associated with obesity, male infertility represents a widespread condition that challenges the wellbeing of the couple. In this article, we provide a comprehensive and critical analysis of studies exploring...
Increased body weight negatively impacts male reproductive health through various molecular mechanisms, necessitating further research to enhance diagnostic markers and therapeutic strategies for better management of male infertility.
Weight-centric prevention of cancer
Source : https://pubmed.ncbi.nlm.nih.gov/38495815/
Medical nutrition therapy, exercise, antiobesity medication, and bariatric interventions, might lead to a reduction in cancer risk through weight loss-dependent and independent factors. Further evidence is needed to better determine...
Medical nutrition therapy, exercise, antiobesity medication, and bariatric interventions, might lead to a reduction in cancer risk through weight loss-dependent and independent factors. Further evidence is needed to better determine which population might benefit the most, and the amount of weight loss required to provide a clinically...
Obesity and cardiovascular health
Source : https://pubmed.ncbi.nlm.nih.gov/38243826/
Obesity has risen to epidemic levels worldwide over the past few decades and has become a huge global health burden owing to its direct contribution to the development of some...
Obesity, driven by poor nutrition and sedentary lifestyles, increases cardiovascular disease risk. Prevention efforts must start early, emphasizing healthy habits from pregnancy onwards. Plant-based diets and regular physical activity offer significant health benefits, though weight loss alone remains challenging.
The Effects of Raspberry Consumption on Glycemic Control and Inflammation Markers in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11163149/
Despite observing the health benefits of raspberry consumption in some recent studies, there is still no consensus regarding this effectiveness on inflammatory markers and glycemic control. This study aimed to...
To our knowledge, the present meta-analysis is the first comprehensive evaluation of the efficacy of raspberry in glycemic control and inflammatory markers. Our findings suggested that raspberry consumption can significantly reduce TNF-α and increase insulin concentrations. According to the insufficient and heterogenous studies, more...
Do polyphenols affect body fat and/or glucose metabolism?
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11198119/
Obesity is reaching epidemic proportions with 51% of the population expected to be obese by 2030. Recently, polyphenols have been highlighted as an effective approach to managing obesity and associated...
There were no significant changes in blood glucose observed in the included studies, with only two studies reporting a significant difference in A1c between the groups. Four studies found no difference in HOMA-IR, while one study showed a significant decrease in HOMA-IR in the intervention group compared to the control group. Three studies...
Obesity management for the treatment of type 2 diabetes: emerging evidence and therapeutic approaches
Source : https://pubmed.ncbi.nlm.nih.gov/38903652/
Excess adiposity can contribute to metabolic complications, such as type 2 diabetes mellitus (T2DM), which poses a significant global health burden. Traditionally viewed as a chronic and irreversible condition, T2DM...
Bariatric surgery stands as a highly effective option for managing body weight and T2DM, yielding significant benefits. Yet, its widespread implementation faces scalability challenges, limiting access for many who could potentially benefit. In contrast, GLP-1RAs, and more particularly dual and triple agonists, offer a promising alternative,...
Insulin resistance assessed by short insulin tolerance test and its association with obesity and insulin resistance-related parameters in humans: A pilot randomized trial
Source : https://pubmed.ncbi.nlm.nih.gov/38905235/
The aim of this study was to examine the association of insulin resistance (evaluated by the short insulin tolerance test [SITT]) with parameters related to obesity and insulin resistance. We...
It did not turn out to be the index test. KITT(iv) was associated with clinical parameters such as VFA, adiponectin, and BCAAs. Of note, KITT(iv) is not affected by endogenous insulin unlike HOMA-IR and, thus, the observed associations notably indicated the pathogenetic link of the examined clinical parameters and insulin resistance. KITT(iv)...
The effect of a combined lifestyle intervention with and without protein drink on inflammation in older adults with obesity and type 2 diabetes
Source : https://pubmed.ncbi.nlm.nih.gov/38527636/
13 weeks of combined lifestyle intervention, either with or without protein drink, reduced circulating adipokines and anti-inflammatory cytokine IL-1RA, and increased inflammatory ratios TNF-α/IL-10 and TNF-α/IL-1RA in older adults with...
13 weeks of combined lifestyle intervention, either with or without protein drink, reduced circulating adipokines and anti-inflammatory cytokine IL-1RA, and increased inflammatory ratios TNF-α/IL-10 and TNF-α/IL-1RA in older adults with obesity and T2D. Effect on CLIP was inversely related to baseline inflammatory status.
Mediterranean diet as a strategy for preserving kidney function in patients with coronary heart disease with type 2 diabetes and obesity
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11099022/
Type 2 diabetes mellitus (T2DM) is recognized an independent risk factor for chronic kidney disease (CKD). The precise contribution and differential response to treatment strategies to reduce kidney dysfunction, depending...
Obesity provided an additive effect to T2DM resulting in a more pronounced decline in kidney function compared to T2DM alone when compared to non-diabetics. In patients with concomitant presence of T2DM and obesity, with more metabolic complications, consumption of a Mediterranean diet seemed more beneficial than a low-fat diet in terms of...
Surveillance of the liver in type 2 diabetes: important but unfeasible?
Source : https://pubmed.ncbi.nlm.nih.gov/38334817/
Fatty liver plays a pivotal role in the pathogenesis of the metabolic syndrome and type 2 diabetes. According to an updated classification, any individual with liver steatosis and one or...
Emerging evidence suggests that fibrosis biomarkers may serve as tools for risk-based targeting of weight-loss interventions and potentially for monitoring response to therapy.
SGLT2 inhibitors reduced heart failure events and cardiovascular death in patients with heart failure, type 2 diabetes, chronic kidney disease, and atherosclerotic cardiovascular disease. These effects were consistent across a wide range of subgroups within these populations. This supports the eligibility of a large population with...
The association between bariatric surgery and reduced risk was greatest in women with high levels of insulin at baseline.
Increased Innate Immune Responses in Adolescents With Obesity and its Relation to Subclinical Cardiovascular Measures: an Exploratory Study
Source : https://pubmed.ncbi.nlm.nih.gov/38741712/
Cardiometabolic risk accrues across the life course and childhood and adolescence are key periods for effective prevention. Obesity is associated with inflammation in adults, but pediatric data are scarce. In...
Monocytes from children and adolescents with severe obesity have a pro-inflammatory state compared to controls of the same age with healthy BMI.
The Efficacy of Platelet-Rich Plasma Injection Therapy in Obese Versus Non-Obese Patients With Knee Osteoarthritis: a Comparative Study
Source : https://www.mdpi.com/2077-0383/13/9/2590
Background/Objectives: Obesity is a common comorbidity in knee osteoarthritis (KOA) patients. Platelet-Rich Plasma (PRP) injection therapy may mitigate KOA. To further clarify potential patient selection for PRP injection therapy, we...
Patients with obesity benefited from platelet-rich plasma injections who had knee osteoarthritis.