Obesity Connect
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In this cohort study of 1229 individuals who participated in the Look AHEAD trial, incorporating high physical activity volume and weight loss was associated with a 61% of lower risk of adverse CV events.

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The mediation analyses suggested that ≤94.8% of associations among paternal obesity and offspring cardiometabolic alterations might be mediated by offspring BMI.

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Mobile Health (m-Health) Smartphone Interventions for Adolescents and Adults With Overweight or Obesity

Mobile Health (m-Health) Smartphone Interventions for Adolescents and Adults With Overweight or Obesity

Source : https://pubmed.ncbi.nlm.nih.gov/38375882/

The available evidence is limited and does not demonstrate a clear benefit of smartphone applications as interventions for adolescents or adults with overweight or obesity. While the number of studies...

The available evidence does not demonstrate a clear benefit of smartphone applications as interventions for adolescents or adults with overweight or obesity.

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Obesity and Menopause

Obesity and Menopause

Source : https://pubmed.ncbi.nlm.nih.gov/38343134/

Obesity is not a choice or a result of lack of willpower, but a multifactorial, chronic, progressive, and relapsing disease. During menopause, hormonal and body composition changes lead to greater...

The use of estrogen-only or combined transdermal MHT does not increase the risk of thrombotic events in women with obesity.

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In this cohort study of 4041 patients with sepsis, 33.8% developed early sepsis-associated acute kidney injury (AKI) and patients with obesity had a higher risk of developing early sepsis-associated AKI.

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Using patient-positive language to foster weight loss management

Up to 42% of persons with a BMI of ≥35 kg/m2 have experienced weight discrimination, with women experiencing higher rates than men. Weight stigma, or weight discrimination, is the devaluing of a person because of their weight/body size as well as the negative misconceptions associated with increased weight.

An international joint consensus raised concerns that patients with obesity are often unfairly treated in healthcare settings, with many HCPs holding negative beliefs about obesity and many failing to deliver compassionate care. Weight stigma negatively impacts the quantity and quality of health care by reinforcing the false belief that those with obesity have moral flaws of character.

Fear of being judged by their HCP can result in patient harm because they are less likely to seek care. Paradoxically, exposure to weight stigma can result in their unwillingness to be physically active or avoid it altogether, increase sedentary behaviors, and heighten their risks of depression, anxiety, and social isolation. It can also affect linkage to care, particularly cancer screening.

HCPs may use oversimplified language that minimizes the complexity of chronic weight management. Such a reductionist approach can deprioritize patient concerns, resulting in lower adherence.

Instead, a collaborative approach is crucial so that patients feel they have control of—rather than being blamed for—their health. Experts suggest using a person-centered approach to weight-based discussions that involve behavioral-based, multicomponent interventions and, if those interventions are unsuccessful, adjunct pharmacotherapy or surgery.

How do you promote collaboration and empathy to frame a more patient-centric approach when treating patients who are overweight or obese?

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  • 2yr
    I start by asking how the patients found us, were they referred to our medical clinic. I let them tell their weight loss/weight gain story. We use the term "patients Show More
  • 2yr
    I like to empower the patient and have them give ideas on things they can change. I also like to let them know they are not alone. I am here Show More

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GNAS mutations should be considered in patients with obesity, ectopic ossifications, and thyroid-stimulating hormone resistance presented in early infancy.

Diagnosis and Approach of Pseudohypoparathyroidism Type 1A and Related Disorders During Long Term Follow-Up: a Case Report

Diagnosis and Approach of Pseudohypoparathyroidism Type 1A and Related Disorders During Long Term Follow-Up: a Case Report

Source : https://www.degruyter.com/document/doi/10.1515/jpem-2023-0454/html

Objectives Pseudohypoparathyroidism type 1A (PHP1A) encompasses the association of resistance to multiple hormones, features of Albright hereditary osteodystrophy and decreased Gsα activity. Little is known about the early signs of...

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Orthopedic Manifestations in Children With Prader-Willi Syndrome

Orthopedic Manifestations in Children With Prader-Willi Syndrome

Source : https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-024-04603-7

Prader-Willi syndrome (PWS) is a rare genetic disease often associated with bone problems, mainly scoliosis and hip dysplasia (HD). This study aimed to analyze the clinical characteristics of orthopedic deformities...

The median age of scoliosis was 4.5 years, and the prevalence of scoliosis increased rapidly at the age of 5 years and adolescence.

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A traditional Atlantic dietary intervention significantly reduced the incidence of metabolic syndrome. There was no statistically significant difference in the reduction in dietary carbon footprint emissions in the intervention group compared with the control group.

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Cognitive function, inflammatory biomarkers, comorbidities, physical activity, and depressive symptoms were still improved 2 years after bariatric surgery.

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Chronic Kidney Disease on the Background of Bardet-Biedl Syndrome: a Case Report and Review of Literature

Chronic Kidney Disease on the Background of Bardet-Biedl Syndrome: a Case Report and Review of Literature

Source : https://journals.lww.com/annals-of-medicine-and-surgery/fulltext/2024/02000/chronic_kidney_disease_on_the_background_of.76.aspx

An 18-year-old male presented to the emergency department with chief complaints of fever, cough, vomiting, and decreased urine output for 7 days. Parents complained that the child had a delay...

The management of chronic kidney disease in the background of Bardet-Biedl syndrome poses unique challenges due to the complex multisystem involvement of this genetic disorder.

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Evaluation of Health-Related Quality of Life in Adolescents With Obesity: a Randomized Qualitative Study Among Healthcare Professionals

Evaluation of Health-Related Quality of Life in Adolescents With Obesity: a Randomized Qualitative Study Among Healthcare Professionals

Source : https://www.cureus.com/articles/212270-evaluation-of-health-related-quality-of-life-in-adolescents-with-obesity-a-randomized-qualitative-study-among-healthcare-professionals

Adolescent obesity constitutes a disorder with physical and psychosocial implications. Childhood and adolescent obesity rates are constantly increasing worldwide. Since adolescent obesity is a chronic disease, which is part of...

Researchers identified that a structured tool implementation to assess health-related quality of life in daily clinical routine is an unmet need for pediatricians treating adolescents with obesity.

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Exploring the Comorbidity Mechanisms Between Psoriasis and Obesity Based on Bioinformatics

Exploring the Comorbidity Mechanisms Between Psoriasis and Obesity Based on Bioinformatics

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10818127/

Psoriasis is a chronic, recurrent, immune‐mediated inflammatory skin disease characterized by erythematous scaly lesions. Obesity is currently a major global health concern, increasing the risk of diseases such as cardiovascular...

Psoriasis and obesity may mutually influence each other through multiple targets and pathways, emphasizing the importance of considering comorbidity treatment and daily care in clinical practice.

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Obesity/Cardiometabolic Phenotype of Heart Failure With Persevered Ejection Fraction: Mechanisms to Recent Trials

Obesity/Cardiometabolic Phenotype of Heart Failure With Persevered Ejection Fraction: Mechanisms to Recent Trials

Source : https://pubmed.ncbi.nlm.nih.gov/38294186/

The obesity phenotype of HFpEF is seen in upward of 80% with HFpEF. Obesity is not just a bystander, but plays an essential role in the pathobiology and clinical course...

Emerging data suggest that inflammatory biomarkers, specifically, interleukin 6, may provide useful information about heart failure with preserved ejection fraction severity and symptom burden in obesity.

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Efficacy and Safety of Non-Vitamin-K Antagonist Oral Anticoagulants Versus Warfarin Across the Spectrum of Body Mass Index and Body Weight: an Individual Patient Data Meta-Analysis of Four Randomized Clinical Trials of 58464 Patients With Atrial Fibrillat

Efficacy and Safety of Non-Vitamin-K Antagonist Oral Anticoagulants Versus Warfarin Across the Spectrum of Body Mass Index and Body Weight: an Individual Patient Data Meta-Analysis of Four Randomized Clinical Trials of 58464 Patients With Atrial Fibrillat

Source : https://pubmed.ncbi.nlm.nih.gov/38264923/

The treatment effect of NOAC versus warfarin in atrial fibrillation is generally consistent for stroke/SEE across the spectrum of BMI and BW, whereas the reduction in major bleeding is attenuated...

The treatment effect of non-vitamin-K antagonist oral anticoagulants versus warfarin in atrial fibrillation is generally consistent for stroke across the spectrum of BMI and body weight, whereas the reduction in major bleeding is attenuated at a higher BMI and body weight.

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Change in Weight Status Among Children Who Do and Do Not Participate in Intensive Health Behavior and Lifestyle Treatment for Obesity

Change in Weight Status Among Children Who Do and Do Not Participate in Intensive Health Behavior and Lifestyle Treatment for Obesity

Source : https://pubmed.ncbi.nlm.nih.gov/38265804/

Primary care providers (PCPs) are expected to provide weight management counseling despite having low confidence in their ability to be effective.

Although structured weight management programs have a significant impact on weight status, those who received some counseling did not show significant increases in weight status and were relatively weight stable.

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The Relationship Between Hedonic Hunger and Self-Stigmatisation in Terms of Weight and Self-Esteem in Adult People Living With Obesity

The Relationship Between Hedonic Hunger and Self-Stigmatisation in Terms of Weight and Self-Esteem in Adult People Living With Obesity

Source : https://pubmed.ncbi.nlm.nih.gov/38234175/

As hedonic hunger increased in adults with overweight, self-esteem decreased, and self-stigmatisation in terms of weight increased. Effective interventions are needed to cope with the hedonic hunger that contributes to...

As hedonic hunger increased in adults with overweight, self-esteem decreased, and self-stigmatization in terms of weight increased.

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Effects of Blood Flow Restriction Training on Muscle Fitness and Cardiovascular Risk of Obese College Students

Effects of Blood Flow Restriction Training on Muscle Fitness and Cardiovascular Risk of Obese College Students

Source : https://pubmed.ncbi.nlm.nih.gov/38235388/

The aim of this study was to investigate the effect of blood flow restriction (BFR) combined with low-intensity resistance training (RT) on cardiovascular risk factors in obese individuals. Twenty-six male...

Blood flow restriction with low-intensity resistance training effectively improved body composition index, increased muscle mass, improved neuromuscular activation, and enhanced muscle strength and endurance.

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Metabolic Surgery in Improving Arterial Health in Obese Individuals

Metabolic Surgery in Improving Arterial Health in Obese Individuals

Source : https://pubmed.ncbi.nlm.nih.gov/38128633/

Metabolic surgery is associated with a significant decrease in the occurrence of major adverse cardiovascular events (MACE) and all-cause mortality among obese individuals, alongside remarkable enhancement of arterial health.

Metabolic surgery is associated with a significant decrease in the occurrence of major adverse cardiovascular events and all-cause mortality among obese individuals.

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Pharmacotherapy for Obesity: Moving Towards Efficacy Improvement

Pharmacotherapy for Obesity: Moving Towards Efficacy Improvement

Source : https://dmsjournal.biomedcentral.com/articles/10.1186/s13098-023-01233-4

Obesity is a chronic, recurring, progressive disease and a major public health problem associated with several other diseases that lead to disability, morbidity, and mortality. The prevalence of obesity has...

Semaglutide changes the overall landscape of obesity care, as phase 3 studies show a mean weight loss near the 15% threshold and significant proportions of patients with a weight loss of >20%.

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