Bariatric Surgery in Prospective Obese Living Kidney Donors: Scoping Review and Management Decision Algorithm
Source : https://pubmed.ncbi.nlm.nih.gov/38127433/
BS shows promise with short-term effectiveness and potential long-term outcomes. However, it should not be perceived as a means to expand the donor pool but rather as a personalized approach...
Cost-benefit analysis favors bariatric surgery over nephrectomy in obese donors (cost-benefit ratio: 3.64) when graft survival is equal.
Effect of Carbohydrate Restriction on Body Weight in Overweight and Obese Adults: a Systematic Review and Dose-Response Meta-Analysis of 110 Randomized Controlled Trials
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10731359/
Carbohydrate-restricted diets are one of the most effective dietary interventions for weight loss. However, the optimum carbohydrate intake for implementing the most effective weight-loss interventions is still being discussed. We...
If the goal is to achieve weight loss in the short term, a low-carbohydrate diet could produce a greater weight-loss effect, and it is recommended to keep protein 20%-25% of calorie intake.
Effect of Remotely Supervised Weight Loss and Exercise Training Versus Lifestyle Counseling on Cardiovascular Risk and Clinical Outcomes in Older Adults With Rheumatoid Arthritis: a Randomized Controlled Trial
Source : https://pubmed.ncbi.nlm.nih.gov/38126260/
In older patients with RA and overweight/obesity, 16 weeks of remotely supervised weight loss, aerobic training, and resistance training improve cardiometabolic health, patient-reported outcomes, and disease activity.
The Impact of Early-Stage Chronic Kidney Disease on Weight Loss Outcomes After Gastric Bypass
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10687110/
Weight loss achieved through bariatric metabolic surgery was demonstrated to be effective at reversing chronic kidney dysfunction associated with obesity-related glomerulopathy.
After bariatric metabolic surgery, there was a statistically significant reduction in body weight and BMI (P<0.0001).
Alterations in the Mammary Gland and Tumor Microenvironment of Formerly Obese Mice
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693119/
Obesity is a risk factor for breast cancer, and women with obesity that develop breast cancer have a worsened prognosis. Within the mammary gland, obesity causes chronic, macrophage-driven inflammation and...
Although weight loss did not completely reduce the rate of tumor growth, the microenvironment of the resulting tumors was less fibrotic and immunosuppressive than tumors from obese mice.
Social Jetlag and Obesity: a Systematic Review and Meta-Analysis
Source : https://pubmed.ncbi.nlm.nih.gov/38072635/
Social jetlag, the weekly variation in sleep timing, is proposed to contribute to increased obesity risk, potentially because of the misalignment of behavioral cycles relative to the endogenous circadian timing...
Social jetlag, the weekly variation in sleep timing, was positively and consistently associated with multiple obesity-related anthropometric measures.
Team-Based Learning Intervention to Improve Obesity Education in Medical School
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689578/
Obesity is a multifactorial chronic disease and a major contributor to numerous health conditions. Despite the high prevalence, costs, and health effects of obesity, physicians are largely unprepared to treat...
Medical student attitudes toward obesity and self-perceived knowledge of obesity significantly improved after a 2-part team-based learning (TBL) seminar on obesity pathogenesis and treatment. As TBLs are being increasingly utilized in medical curricula across the country, this study provides a model to improve obesity education at the...
Effects of Semaglutide on Symptoms, Function, and Quality of Life in Patients With Heart Failure With Preserved Ejection Fraction and Obesity: a Prespecified Analysis of the STEP-HFpEF Trial
Source : https://pubmed.ncbi.nlm.nih.gov/37952180/
Patients with heart failure (HF) with preserved ejection fraction (HFpEF) and obesity experience high burden of symptoms and functional impairment, and a poor quality of life.
In patients with HFpEF and obesity, semaglutide produced large improvements in HF-related symptoms, physical limitations, exercise function, inflammation, body weight and NTproBNP regardless of baseline health status.
Effects of Combined Aerobic Exercise and Diet on Cardiometabolic Health in Patients With Obesity and Type 2 Diabetes: a Systematic Review and Meta-Analysis
Source : https://bmcsportsscimedrehabil.biomedcentral.com/articles/10.1186/s13102-023-00766-5
Lifestyle modifications involving diet and exercise are recommended for patients diagnosed with obesity and type 2 diabetes mellitus (T2DM). The purpose of this review was to systematically evaluate the effects...
The study results indicated that AEDT exerts beneficial changes in body composition, lipid and glucose metabolism, blood pressure, adipose tissue dysfunction, and inflammation in patients with T2DM and concurrent obesity.
Efficacy and Safety of Semaglutide 2.4 mg According to Antidepressant Use at Baseline: a Post Hoc Subgroup Analysis
Source : https://pubmed.ncbi.nlm.nih.gov/37989717/
In adults with overweight/obesity, semaglutide provided clinically meaningful weight loss regardless of baseline AD use, with an AE profile consistent with previous studies.
Regardless of antidepressant use, semaglutide 2.4 mg is an effective treatment option for overweight/obesity, and adverse events are generally similar between placebo and semaglutide 2.4 mg.
The Relation Between Excess Adiposity and Breast Cancer in Women: Clinical Implications and Management
Source : https://www.sciencedirect.com/science/article/pii/S1040842823003013?via=ihub
Breast cancer (BC) is the most common cancer in women. While the combination of improved screening, earlier detection, and advances in therapeutics ha...
Weight gain prevention and weight loss interventions should ideally be seamlessly included in the management of BC to provide a holistic, individualized approach to improve health and survival in this population.
Semaglutide and Tirzepatide Reduce Alcohol Consumption in Individuals With Obesity
Source : https://www.nature.com/articles/s41598-023-48267-2
Alcohol Use Disorder (AUD) contributes significantly to global mortality. GLP-1 (Glucagon-like peptide-1) and GLP-1/GIP (Glucose-dependent Insulinotropic Polypeptide) agonists, FDA-approved for managing type 2 diabetes and obesity, where the former has...
Researchers observed a reduction in average number of drinks, binge drinking, AUDIT score, and the sedative/stimulating effects of alcohol in individuals taking semaglutide or tirzepatide.
The Effect of Acarbose on Lipid Profiles in Adults: a Systematic Review and Meta-Analysis of Randomized Clinical Trials
Source : https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.1186/s40360-023-00706-6
Dyslipidemia, characterized by elevated levels of triglycerides (TG), low-density lipoprotein (LDL), total cholesterol (TC), and reduced levels of high-density lipoprotein (HDL), is a major risk factor for cardiovascular diseases (CVD)....
The findings of this study suggest that acarbose can reduce serum levels of TG and TC; however, no significant effects were observed on LDL or HDL levels.
Weight Management Interventions for Adults With Idiopathic Intracranial Hypertension
Source : https://n.neurology.org/content/101/21/e2138.long
Idiopathic intracranial hypertension (IIH) is associated with obesity; however, there is a lack of clinical consensus on how to manage weight in IIH. The aim of this systematic review was...
The biological drivers of obesity may explain why short-term weight management interventions are often insufficient for long-term disease remission. The hierarchy of effect in weight loss methods seems to be analogous to the reduction of ICP, with bariatric surgery having the most robust evidence for effective treatment of obesity in the IIH...
Researchers review various high-impact studies that link epigenetics with metabolic syndrome by comparing each study population, methylation effects, and strengths and weaknesses of each research.
Irisin and Cardiometabolic Disorders in Obesity: a Systematic Review
Source : https://www.hindawi.com/journals/iji/2023/5810157/
Overweight and obesity are global health issues, impacting a significant portion of young adults. Obesity is a complex condition influenced by genetics and environmental factors, leading to increased susceptibility to...
The review suggests that irisin plays a significant role as both a preventive measure and a biomarker for comorbidities linked to obesity and cardiometabolic disorders.
Effect of Combined Administration of Acyl-CoA: Cholesterol Acyltransferase 1 Inhibitor and Glucagon-Like Peptide 1 Receptor Agonist on a Rodent Model of Diet-Induced Obesity
Source : https://www.sciencedirect.com/science/article/abs/pii/S0006291X23012585?via=ihub
A glucagon-like peptide 1 receptor agonist (GLP-1 RA) semaglutide was approved for the treatment of obesity by the Food and Drug Administration. Howev...
Collectively, these findings suggest combining semaglutide and avasimibe could be an effective approach to weight management.
Impact of a Pharmacist-Led Weight Management Service in a Cardiology Clinic
Source : https://pubmed.ncbi.nlm.nih.gov/37944862/
Pharmacist-led management of GLP-1 RA in patients with obesity or overweight led to clinically significant weight loss and improvements in weight-related comorbidities.
Pharmacist-led management of GLP-1 RA in patients with obesity or overweight led to clinically significant weight loss and improvements in weight-related comorbidities.
Are We Ready to Recommend Capsaicin for Disorders Other Than Neuropathic Pain?
Source : https://www.mdpi.com/2072-6643/15/20/4469
Capsaicin, a lipophilic, volatile compound, is responsible for the pungent properties of chili peppers. In recent years, a significant increase in investigations into its properties has allowed the production of...
Type 2 diabetes and dyslipidemia are closely linked to obesity and, consequently, could be beneficiated by capsaicin supplementation.
Effect of Long-Acting Versus Short-Acting Glucagon-Like Peptide-1 Receptor Agonists on Improving Body Weight and Related Metabolic Parameters in Type 2 Diabetes: a Head-to-Head Meta-Analysis
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615555/
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) showed great value in treating nonalcoholic fatty liver disease (NAFLD).
Long-acting GLP-1RAs may be more promise than short-acting GLP-1RAs in improving weight and related metabolic parameters.