Acute pharmacodynamic responses to exenatide: Drug-induced increases in insulin secretion and glucose effectiveness
Source : https://www.medrxiv.org/content/10.1101/2023.03.15.23287166v1
Background GLP1R agonists provide multiple benefits to patients with type 2 diabetes - including improved glycemic control, weight loss, and decreased risk of major adverse cardiovascular events. Because drug responses...
Conclusions: This pilot study provides validation for the value of an FSIGT (including minimal model analysis) to provide primary data for our ongoing pharmacogenomic study of pharmacodynamic effects of semaglutide. Three endpoints provide quantitative assessments of GLP1R agonist effects on glucose metabolism: first phase insulin...
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Dermal Hypersensitivity Reaction to Semaglutide: Two Case Reports - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37026881/
Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of antidiabetic agents that work by inducing insulin secretion and inhibiting release of glucagon in a glucose-dependent manner. They are especially promising...
Relevance: In the first case, a 75-year-old woman who had been taking semaglutide for 10 months presented with an eruption on her legs, back, and chest for 3 months duration. Histology showed a subepidermal blister with eosinophils, suggestive of a drug hypersensitivity reaction. In the second case, a 74-year-old white man who had been...
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Microbiota-gut-brain axis: relationships among the vagus nerve, gut microbiota, obesity, and diabetes - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37058160/
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Conclusions: Because of its enteroendocrine cell-mediated interaction with the gut microbiota, the vagus nerve may provide a potential pathway through which gut microorganisms influence host feeding behavior and metabolic control of physiological and pathological conditions.
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Sodium Glucose Cotransporter 2 (SGLT2) Inhibitor Ameliorate Metabolic Disorder and Obesity Induced Cardiomyocyte Injury and Mitochondrial Remodeling - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37047815/
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Conclusions: Our study reveals the adverse effects of metabolic disorder- and obesity-induced epicardial fat impairing cardiomyocyte H9c2 function by disturbing the mitochondrial function, such as reducing membrane potential, ROS accumulation, Ca2+ overload, and associated regulator expression. However, most of the dysregulation was...
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New insights into the treatment of obesity - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37055715/
Obesity is a chronic, progressive, and relapsing disease with a rising global prevalence associated with increased morbidity and mortality and reduced quality of life. Treatment of obesity requires a comprehensive...
Conclusions/Relevance: these novel agents promise to narrow the gap between the weight-loss effects of behavior interventions, previous pharmacotherapies, and bariatric surgery. In this narrative review, we highlight established and emerging therapeutic treatments for long-term obesity management and position them in a framework according to...
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