micro-community-banner
 
Profile Image
  • Add Media
  • Saved

6mo
Obesity and its management in primary care setting - PubMed

Obesity and its management in primary care setting - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/40305970/

Obesity is a worldwide epidemic affecting adults and children, regardless of their socioeconomic status. Significant progress has been made in understanding the genetic causes contributing to obesity, shedding light on...

Obesity impacts all ages globally, causing serious complications. Prevention, especially in children, and treatment through lifestyle, surgery, and new drugs like GLP-1RAs are crucial, with primary care central.

Profile Image
  • Saved

6mo

The GLP-1 agonists work very well. The major problem is Insurance, not covering it to many many people who would benefit from it. It’s heartbreaking to keep this life altering medication from them due to lack of financial resources and lack of insurance coverage.

Profile Image
  • Saved

6mo
Severe obesity with hypo-leptinemia - PubMed

Severe obesity with hypo-leptinemia - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/40128964/

Some cases of obesity are thought to be associated with hypo-leptinemia. This may cause decreased appetite suppression resulting in increased appetite, leading to weight gain. Replacement therapy with leptin might...

A case of severe obesity with hypo-leptinemia, absent leptin gene mutations, suggests possible hypothalamic dysfunction and abnormal adipocyte expansion; leptin-replacement therapy may benefit such patients.

Profile Image
  • Saved

6mo
The Microbiota and Evolution of Obesity - PubMed

The Microbiota and Evolution of Obesity - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/39673174/

Obesity is a major global concern and is generally attributed to a combination of genetic and environmental factors. Several hypotheses have been proposed to explain the evolutionary origins of obesity...

This review proposes that immune system evolution and pathogen defense (metaflammation), combined with gut microbiota genetics, contribute to obesity's origins, emphasizing a multifactorial, evolutionary and polygenic understanding of the epidemic.

Profile Image
  • Saved

6mo
GLP-1 Therapies in Metabolic and Hormonal Health: ENDO 2025 Insights

At ENDO 2025, Dr. Monica Laronda (Lurie Children’s Hospital, Northwestern University) highlighted emerging research investigating how GLP-1 therapies and rising obesity rates may influence puberty onset, menarche timing, and sex-specific disease expression—particularly in adolescents with high BMI or genetic susceptibility. She also discussed environmental and epigenetic drivers of endocrine disruption and underscored the need to consider sex as a biological variable in metabolic research. Dr. Shellsea Portillo (St. Louis University Hospital) presented retrospective data indicating that GLP-1–associated weight loss significantly improved testosterone levels in obese men with type 2 diabetes, suggesting a possible avenue for further exploration as a non-hormonal strategy for managing obesity-related hypogonadism. Together, these insights underscore GLP-1’s emerging but preliminary role in reproductive and metabolic endocrine health.

Profile Image