Source : https://pubmed.ncbi.nlm.nih.gov/39496581/
White adipose tissue (WAT) is crucial for whole-body energy homeostasis and plays an important role in metabolic and hormonal regulation. While healthy WAT undergoes controlled expansion and contraction to meet...
Obesity-induced white adipose tissue dysfunction promotes cancer through systemic inflammation, altered metabolism, and tumor microenvironment remodeling, establishing bidirectional interactions that support tumor growth and reveal potential therapeutic targets.
In a phase 2b study, efruxifermin added to stable GLP-1RA therapy in MASH patients with T2D was safe and reduced hepatic fat fraction by 65% vs. 10% with GLP-1RA alone. It also improved noninvasive fibrosis and metabolic markers without impacting weight loss benefits.
Did you know? Statins are linked to a 9–12% increased risk of new-onset diabetes, particularly with long-term, high-dose use and in patients with impaired glucose regulation. Still, their cardiovascular benefits usually outweigh this risk, prompting continued use in most at-risk populations.
Could statins’ effects on insulin release and sensitivity explain their role in glucose abnormalities?
Could statins’ effects on insulin release and sensitivity explain their role in glucose abnormalities?
Source : https://pubmed.ncbi.nlm.nih.gov/38225284/
Weight regain and insufficient weight loss are essential problems after metabolic bariatric surgery (MBS) in people living with obesity. Changes in the level of glucagon-like peptide-1 (GLP-1) secreted from the...
This review highlights post-bariatric surgery GLP-1 changes linked to weight loss success and suggests GLP-1 receptor agonists as promising treatments for weight regain or insufficient weight loss after surgery.