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ADA 2025 Highlights: Obesity Therapies, Islet Cell Advances, and Oral GLP-1 Outcomes in T2D

At ADA 2025, Dr. Mark Atkinson (University of Florida Diabetes Institute) highlighted the systemic benefits of obesity-targeted therapies, including cardiometabolic and cognitive improvements, while noting concerns about implementation and potential muscle loss. Emerging advances in stem cell–derived islet transplantation for type 1 diabetes show promise in reducing insulin dependence. Dr. John Buse (University of North Carolina) presented SOUL trial data indicating that oral GLP-1 receptor agonist therapy reduced major adverse cardiovascular events—CV death, nonfatal MI, or stroke—by 14%, with additional reductions in limb complications in high-risk patients with type 2 diabetes.

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Enhancing gut microbiota and microbial function with inulin supplementation in children with obesity - PubMed

Enhancing gut microbiota and microbial function with inulin supplementation in children with obesity - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/39033197/

Inulin supplementation significantly promoted gut bacterial diversity and improved gut microbiota dysbiosis in children with obesity. The modulation of functional pathways by inulin suggests its potential to establish beneficial interactions...

 

Inulin supplementation in children with obesity improved gut microbiota diversity, increased beneficial bacterial populations, and modulated functional pathways, suggesting its potential as a therapeutic strategy for microbiota restoration and metabolic improvement.

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Obesity pharmacotherapy in older adults: a narrative review of evidence - PubMed

Obesity pharmacotherapy in older adults: a narrative review of evidence - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/38710803/

The prevalence of obesity in older adults (people aged >60 years) is increasing in line with the demographic shift in global populations. Despite knowledge of obesity-related complications in younger adults...

 

Obesity in older adults poses unique risks, but intentional weight loss—via lifestyle changes and emerging anti-obesity medications—can be safe and effective, improving health while preserving muscle and functional ability.

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Approach to Obesity Treatment in Primary Care: A Review - PubMed

Approach to Obesity Treatment in Primary Care: A Review - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/38466272/

Primary care clinicians play a vital role in the assessment, management, and support of patients with obesity. With careful clinical assessment and shared decision-making, a flexible treatment plan can be...

 

Effective obesity care in primary settings requires integrating lifestyle changes with adjunctive therapies like antiobesity medications or surgery, enabling sustained weight loss and health gains through individualized, evidence-based treatment plans.

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Exercise as a Therapeutic Strategy for Obesity: Central and Peripheral Mechanisms - PubMed

Exercise as a Therapeutic Strategy for Obesity: Central and Peripheral Mechanisms - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/39590824/

Obesity is a complex, multifactorial condition involving excessive fat accumulation due to an imbalance between energy intake and expenditure, with its global prevalence steadily rising. This condition significantly increases the...

 

Exercise combats obesity by modulating central nervous system functions and enhancing peripheral metabolic processes, promoting fat oxidation and energy balance; deeper insight into these interactions can improve obesity management strategies.

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