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Did you know? Statins are linked to a 9–12% increased risk of new-onset diabetes, particularly with long-term, high-dose use and in patients with impaired glucose regulation. Still, their cardiovascular benefits usually outweigh this risk, prompting continued use in most at-risk populations.

Could statins’ effects on insulin release and sensitivity explain their role in glucose abnormalities?

Statins

Could statins’ effects on insulin release and sensitivity explain their role in glucose abnormalities?

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Post metabolic bariatric surgery weight regain: the importance of GLP-1 levels - PubMed

Post metabolic bariatric surgery weight regain: the importance of GLP-1 levels - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/38225284/

Weight regain and insufficient weight loss are essential problems after metabolic bariatric surgery (MBS) in people living with obesity. Changes in the level of glucagon-like peptide-1 (GLP-1) secreted from the...

 

This review highlights post-bariatric surgery GLP-1 changes linked to weight loss success and suggests GLP-1 receptor agonists as promising treatments for weight regain or insufficient weight loss after surgery.

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ADA 2025 Highlights: Obesity Therapies, Islet Cell Advances, and Oral GLP-1 Outcomes in T2D

At ADA 2025, Dr. Mark Atkinson (University of Florida Diabetes Institute) highlighted the systemic benefits of obesity-targeted therapies, including cardiometabolic and cognitive improvements, while noting concerns about implementation and potential muscle loss. Emerging advances in stem cell–derived islet transplantation for type 1 diabetes show promise in reducing insulin dependence. Dr. John Buse (University of North Carolina) presented SOUL trial data indicating that oral GLP-1 receptor agonist therapy reduced major adverse cardiovascular events—CV death, nonfatal MI, or stroke—by 14%, with additional reductions in limb complications in high-risk patients with type 2 diabetes.

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Enhancing gut microbiota and microbial function with inulin supplementation in children with obesity - PubMed

Enhancing gut microbiota and microbial function with inulin supplementation in children with obesity - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/39033197/

Inulin supplementation significantly promoted gut bacterial diversity and improved gut microbiota dysbiosis in children with obesity. The modulation of functional pathways by inulin suggests its potential to establish beneficial interactions...

 

Inulin supplementation in children with obesity improved gut microbiota diversity, increased beneficial bacterial populations, and modulated functional pathways, suggesting its potential as a therapeutic strategy for microbiota restoration and metabolic improvement.

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