The Pandemic Within the Pandemic: Unprecedented Rise in Alcohol-related Hepatitis During the COVID-19 Pandemic - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34653062/
Our study revealed drastic increases in severe alcohol-related hepatitis requiring inpatient management, specifically in patients under the age of 40 and in women during the COVID-19 pandemic. Given the high...
Conclusions: Our study revealed drastic increases in severe alcohol-related hepatitis requiring inpatient management, specifically in patients under the age of 40 and in women during the COVID-19 pandemic. Given the high morbidity and mortality associated with severe alcohol-related hepatitis, these findings have far-reaching and lasting...
Influence of Sex on Respiratory Syncytial Virus Genotype Infection Frequency and Nasopharyngeal Microbiome - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36815771/
Respiratory syncytial virus (RSV) has a significant health burden in children, older adults, and the immunocompromised. However, limited effort has been made to identify emergence of new RSV genotypes' frequency...
Importance: Overall, we show sex differences in RSV genotype-nasopharyngeal microbiome, suggesting an interaction host genetics-virus-microbiome interaction.
Interim Clinical Treatment Considerations for Severe Manifestations of Mpox — United States, February 2023
Source : https://www.cdc.gov/mmwr/volumes/72/wr/mm7209a4.htm?s_cid=mm7209a4_w
Please note: This report has been corrected. Agam K. Rao, MD 1; Caroline A. Schrodt, MD 1; Faisal S. Minhaj, PharmD 1 ,2; Michelle A. Waltenburg, DVM 3; Shama Cash-Goldwasser,...
A single-dose F1-based mRNA-LNP vaccine provides protection against the lethal plague bacterium - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36888708/
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We designed a nucleoside-modified mRNA-LNP vaccine based on the bacterial F1 capsule antigen, a major protective component of Yersinia pestis, the etiological agent of plague. Plague is a rapidly deteriorating contagious disease that has killed millions of people during the history of humankind. Now, the disease is treated effectively with...
Innate immune cell activation causes lung fibrosis in a humanized model of long COVID - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36848564/
COVID-19 remains a global pandemic of an unprecedented magnitude with millions of people now developing "COVID lung fibrosis." Single-cell transcriptomics of lungs of patients with long COVID revealed a unique...
These studies revealed that COVID mediated chronic immune activation reminiscent to long COVID in humans. It was characterized by increased CD47, IL-6, and phospho-JUN (pJUN) expression which correlated with disease severity and pathogenic fibroblast populations. When we subsequently treated a humanized COVID lung fibrosis model by combined...