Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease
Source : https://www.sciencedirect.com/science/article/pii/S1074761323000791
Pan-betacoronavirus neutralizing antibodies may hold the key to developing broadly protective vaccines against novel pandemic coronaviruses and to mor...
Highlights
- Isolated a large panel of stem-helix bnAbs from SARS-2 recovered-vaccinated humans
- Stem-helix bnAbs possess recurrent germline features desired for targeted vaccines
- IGHV1-46 encoded stem-helix bnAbs are public clonotypes with two binding modes
- Stem-helix bnAbs prophylactically protect against SARS-1, SARS-2 & MERS challenge
Detection of Streptococcus pyogenes M1UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA - Nature Communications
Source : https://www.nature.com/articles/s41467-023-36717-4
A variant of group A Streptococcus serotype M1 (UK) has been increasingly reported and can be differentiated from the global variant by its overexpression of the superantigen SpeA. Here, Davies...
A single SNP in the 5’ transcriptional leader sequence of the transfer-messenger RNA gene ssrA drives enhanced SpeA superantigen expression as a result of ssrA terminator read-through in the M1UK lineage. This represents a previously unappreciated mechanism of toxin expression and urges enhanced international surveillance.
Highlights
- XCR1 DCs are more functional and less prone to LCMV infection than SIRPα DCs
- Expanding XCR1 DCs via Flt3L or delivering XCR1-targeting Ag improve virus control
- Anti-PD-L1 treatment increases XCR1 DC numbers and IL-12 production
- XCR1 DCs promote TEX functionality but are dispensable for TPEX proliferation burst
Early Estimates of Bivalent mRNA Vaccine Effectiveness in Preventing COVID-19–Associated Emergency Department or Urgent Care Encounters and Hospitalizations Among Immunocompetent Adults
Source : https://www.cdc.gov/mmwr/volumes/71/wr/mm715152e1.htm?s_cid=mm715152e1_w
On December 16, 2022, this report was posted online as an MMWR Early Release. Mark W. Tenforde, MD, PhD 1; Zachary A. Weber, PhD 2; Karthik Natarajan, PhD 3 ,4;...
Bivalent booster doses provided additional protection against COVID-19–associated emergency department/urgent care encounters and hospitalizations in persons who previously received 2, 3, or 4 monovalent vaccine doses. Because of waning of monovalent vaccine-conferred immunity, relative effectiveness of bivalent vaccines was higher with...
Massive regulatory changes can be found in monocytes of COVID-19 patients. Interaction of C/EBPs with gene LUCAT1 highlighted the epigenetic regulator.