micro-community-banner
 
  • Saved

2yr

XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections

Source : https://doi.org/10.1016/j.celrep.2023.112123



Highlights


  • XCR1 DCs are more functional and less prone to LCMV infection than SIRPα DCs
  • Expanding XCR1 DCs via Flt3L or delivering XCR1-targeting Ag improve virus control
  • Anti-PD-L1 treatment increases XCR1 DC numbers and IL-12 production
  • XCR1 DCs promote TEX functionality but are dispensable for TPEX proliferation burst

  • Saved

2yr
Early Estimates of Bivalent mRNA Vaccine Effectiveness in Preventing COVID-19–Associated Emergency Department or Urgent Care Encounters and Hospitalizations Among Immunocompetent Adults

Early Estimates of Bivalent mRNA Vaccine Effectiveness in Preventing COVID-19–Associated Emergency Department or Urgent Care Encounters and Hospitalizations Among Immunocompetent Adults

Source : https://www.cdc.gov/mmwr/volumes/71/wr/mm715152e1.htm?s_cid=mm715152e1_w

On December 16, 2022, this report was posted online as an MMWR Early Release. Mark W. Tenforde, MD, PhD 1; Zachary A. Weber, PhD 2; Karthik Natarajan, PhD 3 ,4;...



Bivalent booster doses provided additional protection against COVID-19–associated emergency department/urgent care encounters and hospitalizations in persons who previously received 2, 3, or 4 monovalent vaccine doses. Because of waning of monovalent vaccine-conferred immunity, relative effectiveness of bivalent vaccines was higher with...

  • Saved

2yr

Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19

Source : https://doi.org/10.1016/j.xgen.2022.100232



Massive regulatory changes can be found in monocytes of COVID-19 patients. Interaction of C/EBPs with gene LUCAT1 highlighted the epigenetic regulator.

  • Saved

2yr
Early Treatment with Pegylated Interferon Lambda for Covid-19 - PubMed

Early Treatment with Pegylated Interferon Lambda for Covid-19 - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/36780676/

Among predominantly vaccinated outpatients with Covid-19, the incidence of hospitalization or an emergency department visit (observation for >6 hours) was significantly lower among those who received a single dose of...



Conclusions: Among predominantly vaccinated outpatients with Covid-19, the incidence of hospitalization or an emergency department visit (observation for >6 hours) was significantly lower among those who received a single dose of pegylated interferon lambda than among those who received placebo.

  • Saved

2yr

Blood RNA alternative splicing events as diagnostic biomarkers for infectious disease

Source : https://doi.org/10.1016/j.crmeth.2023.100395



Microfluidic PCR diagnostic assay of AS biomarkers achieves greater than 98% accuracy. Our AS biomarkers outperform gene-expression biomarkers in COVID-19 detection.