Personalized aerosolised bacteriophage treatment of a chronic lung infection due to multidrug-resistant Pseudomonas aeruginosa - Nature Communications
Source : https://www.nature.com/articles/s41467-023-39370-z
Bacteriophage therapy has been suggested as an alternative or complementary strategy for the treatment of multidrug resistant (MDR) bacterial infections. Here, we report the favourable clinical evolution of a 41-year-old...
These results demonstrate that clinically significant improvement is achievable by personalised phage therapy even in the absence of complete eradication of P. aeruginosa lung colonization.
Primary oxidative phosphorylation defects lead to perturbations in the human B cell repertoire
Source : https://doi.org/10.3389/fimmu.2023.1142634
IntroductionThe majority of studies on oxidative phosphorylation in immune cells have been performed in mouse models, necessitating human translation. To understand the impact of oxidative phosphorylation (OXPHOS) deficiency on human...
Discussion: Overall, we show that children with MtD display perturbations in the B cell repertoire which may impact humoral immunity and the ability to clear viral infections.
Neutral sphingomyelinase 2 is required for HIV-1 maturation - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37406093/
HIV-1 assembly occurs at the inner leaflet of the plasma membrane (PM) in highly ordered membrane microdomains. The size and stability of membrane microdomains is regulated by activity of the...
In this study, we found that inhibiting the cellular ceramide–generating enzyme neutral sphingomyelinase 2 (nSMase2) in the virus-producer cell elicits a profound defect in particle maturation and infectivity. Similar effects were seen with HIV-2 and simian immunodeficiency virus, whereas several other retroviruses were less affected, or...
Study Uncovers Direct Link Between Blood Group A and a Higher Risk for COVID-19 Infection
Study Uncovers Direct Link Between Blood Group A and a Higher Risk for COVID-19 Infection
Key Points: The receptor binding domain (RBD) of SARS-CoV-2 bears sequence and overall ABO blood binding similarity with human galectins. SARS-CoV-2 preferentially infects blood group A cells, providing a direct link between blood group A expression and increased infection.
COVID-19 and Psychiatric Admissions: A Comparative Study of Pre-pandemic and Post-pandemic Psychosis Admissions in a South Florida Emergency Department
We noticed a subjective increase in psychosis admissions within our emergency department (ED) with the onset of the coronavirus disease 2019 (COVID-19) pandemic. This study aimed to identify trends concerning...
Current research remains conflicted concerning psychiatric ED admissions during COVID-19, with some stating an increase and others finding a decrease. Our data showed a significant statistical increase in the mean number of psychosis cases when comparing pre-pandemic and pandemic admissions. These findings help add pertinent data to...