Shikonin Alleviates Endothelial Cell Injury Induced by ox-LDL via AMPK/Nrf2/HO-1 Signaling Pathway
Source : https://doi.org/10.1155/2021/5881321
The present study aimed to explore the effects of shikonin (SKN) on the damage of human venous endothelial cells (HUVECs) induced by ox-LDL and the underlying molecular mechanism. The HUVECs...
The level of TNF-α, IL-1β, IL-6, vascular cell adhesion molecule-1 (VCAM1), intercellular adhesion molecule-1 (ICAM1), and E-selectin (E-sel) was increased, ROS levels increased, and superoxide dismutase (SOD) level decreased. Moreover, the protein levels of p-AMPK, Nrf2, and HO-1 were decreased. Compared to the ox-LDL group, SKN treatment...
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Conclusion: "Our data show increased discordance between ApoB and LDL-C is associated with cardiometabolic, clinical and dietary abnormalities and that body fat percentage is causal of elevated ApoB."
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This chapter shows the potential of probiotic strains protecting against CVD based on clinical trials, systematic reviews, and meta-analyses. The suggested mechanisms for the hypolipidemic effects of the probiotic are also discussed.
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Dill supplementation significantly improved LDL-C, TG, and TC levels but not HDL-C. Further high quality controlled clinical trials on human is needed for more accurate and confirm conclusion.
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The Agatston Coronary Artery Calcium Score in Statin Users: Recent Insights from the CAC Consortium and Pathways Forward - American College of Cardiology
Background The coronary artery calcium (CAC) burden as reported with the Agatston score 1 is strongly associated with adverse cardiovascular disease (CVD) events. 2-6 CAC scoring using the Agatston method...
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LYNN CRONIN4yrI have had quite a few patients bring discussions of this paper to me with a number of quite bad interpretations of the data and conclusions gleaned from social media. Show More