Presence of familial hypercholesterolemia variants was associated with a 2-fold higher risk of coronary heart disease, even when LDL-C levels were moderately elevated.
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Effect of Supplementation With Probiotics or Synbiotics on Cardiovascular Risk Factors in Patients With Metabolic Syndrome: a Systematic Review and Meta-Analysis of Randomized Clinical Trials
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10801034/
The effectiveness of probiotics or synbiotics in adults with metabolic syndromes (MetS) remains controversial, this meta-analysis will further analyze the effects of probiotics or synbiotics on cardiovascular factors in adults...
Supplementation with probiotics or synbiotics can reduce BMI, LDL-C, and fasting blood glucose in patients with metabolic syndrome, but the findings did not demonstrate a favorable effect on reducing systolic blood pressure.
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Competing Genetic Traits and Their Influence on LDL Cholesterol Concentration in Familial Hypercholesterolemia
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10801839/
Familial hypercholesterolemia is a monogenic disorder that leads to premature atherosclerosis as a result of lifelong exposure to elevated low-density lipoprotein cholesterol (LDL-C). Both genetic traits and lifestyle factors can...
Patients with a family history of hypercholesterolemia and significantly elevated LDL-C without other major comorbidities can be evaluated with genetics to further elucidate their overall CV risk profile and alter management.
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Multi-Trajectories of Triglyceride-Glucose Index and Lifestyle With Cardiovascular Disease: a Cohort Study
Source : https://pubmed.ncbi.nlm.nih.gov/38093279/
Distinct multi-trajectories of TyG levels and lifestyle scores corresponded to differing CVD risks. The CVD risk caused by a high level TyG trajectory remained increased despite adopting healthier lifestyles. These...
The CVD risk caused by a high-level triglyceride-glucose trajectory remained increased despite study participants adopting healthier lifestyles.
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Lipoprotein-Associated Phospholipase A2 Predicts Cardiovascular Death in Patients on Maintenance Hemodialysis: a 7-Year Prospective Cohort Study
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10785463/
Cardiovascular diseases (CVD) is the leading cause of death among maintenance hemodialysis patients, with dyslipidemia being a prevalent complication. The paradoxical relationship between cardiovascular outcomes and established lipid risk markers,...
In this study, when stratified by median values or when assessed as a continuous variable, elevated Lp-PLA2 activity is consistently associated with an increased risk of CV mortality and the occurrence of MACEs.
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