Personalizing atomoxetine dosing in children with ADHD: what can we learn from current supporting evidence - European Journal of Clinical Pharmacology
Source : https://link.springer.com/article/10.1007/s00228-022-03449-1
Purpose There is marked heterogeneity in treatment response of atomoxetine in patients with attention deficit/hyperactivity disorder (ADHD), especially for the pediatric population. This review aims to evaluate current evidence to...
Conclusion: Personalizing atomoxetine dosage may be even more complex than anticipated thus far, but elucidating the best way to tailor the non-stimulant to a patient’s individual need will be achieved by combining two strategies: detailed research in linking the pharmacokinetics and pharmacodynamics in pediatric patients, and better...
Evidence-based prescribing of medications for ADHD: where are we in 2023?
Source : https://www.tandfonline.com/doi/full/10.1080/14656566.2023.2169604
ABSTRACT A large number of randomized controlled trials (RCTs) and observational studies on the pharmacotherapy of ADHD are available. Based on a search in PubMed and PsycInfo (up to 15...
Expert Opinion: A growing body of evidence is informing prescribers on some, but certainly not all, aspects related to the pharmacological treatment of ADHD in the daily clinical practice, with important weaknesses/gaps that need to be addressed. First, evidence synthesis of RCTs is not able to inform decision-making at the individual patient...
Links between excessive daytime sleepiness and EEG power and activation in two subtypes of ADHD
Source : https://www.sciencedirect.com/science/article/abs/pii/S0301051123000212?via=ihub
EEG and sleepiness were examined in two subtypes of AD/HD and controls. * Use of a frontal, single-channel, dry sensor, portable EEG device was validated. * Significant group effects and...
Conclusions: These findings highlight the importance of considering ADHD subtypes and EDS when exploring EEG characteristics, and have important implications for the diagnosis and treatment of children with ADHD.
A Clinical Investigation on ADHD-Traits in Childhood Celiac Disease - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36635891/
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Conclusion: Untreated CD may predispose to ADHD-resembling symptoms. Physicians should be aware of the probability of ADHD misdiagnosing due to ADHD-resembling cognitive and behavioral traits in untreated CD.
Trends in antipsychotic prescribing to children and adolescents in England: cohort study using 2000-19 primary care data
Source : https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(22)00404-7/fulltext
The observed increase in antipsychotic prescriptions over 20 years results from the accumulation of repeated prescriptions to the same individuals combined with an increase in new prescriptions. These findings highlight...
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Interpretation: The observed increase in antipsychotic prescriptions over 20 years results from the accumulation of repeated prescriptions to the same individuals combined with an increase in new prescriptions. These findings highlight the need for continued monitoring of trends in antipsychotic use and, although this was not examined in this...