Factors associated with the high susceptibility to depression of women during the perimenopause - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36479809/
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site. The site is secure....
Conclusion: High susceptibility to depression of perimenopausal women may be related to lower educational level, more severe perimenopausal symptoms, and altered metacognition.
-
Menopause Connect3yrKey Points • Source: Brain and Behavior • Conclusions: “High susceptibility to depression of perimenopausal women may be related to lower educational level, more severe perimenopausal symptoms, and altered metacognition.” • Chinese researchers assessed psychosocial factors Show More
EP089/#784 Low use of hormone therapy in women with early menopause arising from treatment for cervical cancer
Source : https://ijgc.bmj.com/content/32/Suppl_3/A84.2
Objectives Many cervical cancer patients are premenopausal at diagnosis, and the treatment induces early menopause. The aim of this study was to evaluate the frequency of hormone replacement therapy (HRT)...
Conclusion: A small percentage of cervical cancer survivors have adequate information about menopause and HRT, and a smaller proportion receive hormone replacement therapy. These data show the need for attention to these young women who have menopause arising from treatment, and reinforce the importance for survivorship guidelines for cervical...
Association of ß-glucuronidase activity with menopausal status, ethnicity, adiposity, and inflammation in women
le is known about ß-glucuronidase regulation across women's reproductive lifespan. Correlates of serum ß-glucuronidase activity in healthy premenopausal versus postmenopausal women were therefore examined. Methods ß-Glucuronidase activity and C-reactive protein...
Conclusion: ß-Glucuronidase enzyme activity, upon which polyphenol health-related benefits may depend, is not associated with menopausal status. Future studies are required to determine clinical significance and mechanisms driving ß-glucuronidase associations with ethnicity, inflammation, and adiposity in women.
Heart Failure in Menopause: Treatment and New Approaches
Source : https://www.mdpi.com/1422-0067/23/23/15140/htm
Aging is an important risk factor for the development of heart failure (HF) and half of patients with HF have preserved ejection fraction (HFpEF) which is more common in elderly...
Conclusion: Despite all the advances in considering the best options to treat menopause-induced HFpEF, which involves the reduction of cardioprotection due to estrogen depletion, the focus should be the modulation of the RAS and sympathetic system. The combination of the alternatives described and lifestyle changes including physical activity...
Vitamin D supplements and prevalent overactive bladder in women from midlife through older ages
ate the association of vitamin D supplements with prevalent OAB, all of which were reported by participants in 2019 in both NHS cohorts. OAB was defined as the self-reported need...
Conclusion: OAB symptoms are highly prevalent across adult women, including the oldest old, who are often excluded from treatment trials. Despite interest in vitamin D supplementation as a low-cost strategy to address OAB, our findings indicate oral vitamin D is not associated with prevalent OAB in middle-aged and older women.
The correlation of the fecal microbiome with the biochemical profile during menopause: a Brazilian cohort study - BMC Women's Health
Source : https://bmcwomenshealth.biomedcentral.com/articles/10.1186/s12905-022-02063-8
Background Hormonal, biochemical, and metabolic changes after menopause may alter the quality of life of women, leading to vasomotor, psychological, and genitourinary symptoms, and changes in their gut microbiota, which...
Conclusion: The hormonal and metabolic changes during menopause in the population studied were accompanied by a significant change in the fecal microbiota, especially of the genus Clostridium.
Body Composition Analysis in Perimenopausal Women Considering the Influence of Vitamin D, Menstruation, Sociodemographic Factors, and Stimulants Used
Source : https://www.mdpi.com/1660-4601/19/23/15831/htm
(1) The perimenopausal period and menopause are physiological stages of a woman’s life, and they may result in the occurrence of many health problems. The aim of this study was...
Discussion: Non-menstruating women were characterized by elevated body composition parameters, especially adipose tissue mass, visceral adipose tissue, and metabolic age. Women who declared too frequent alcohol consumption showed lower values of phase angle, which may indicate a weaker capacity of cells to conduct metabolic processes and...
The circadian variation of sleep and alertness of postmenopausal women - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36420995/
doi: 10.1093/sleep/zsac272. Online ahead of print. 1 Integrated program in Neuroscience, McGill University, Montreal, Quebec, Canada. 2 Centre for Study and Treatment of Circadian Rhythms, Douglas Mental Health University Institute,...
Conclusion: These results support the hypothesis of a weakened circadian signal promoting sleep and wakefulness in older women. Aging processes including hormonal changes may be main contributors to the increased sleep-wake disturbances after menopause.
Priorities for alleviating menopausal symptoms after cancer : Menopause
ht sweats," "mood changes," "vaginal dryness or soreness," "sleep disturbances," "feeling tired or worn out (fatigue)," "sexual problems and/or pain with intercourse," "joint pain," and "something else" with free-text response....
Conclusion: Vasomotor symptoms, fatigue, sexual problems, and vaginal dryness/soreness were the leading priorities for treatment. Understanding symptom severity and patient priorities will inform better care for this growing population.
Practice patterns and perspectives regarding treatment for... : Menopause
tely). Methods Registered US gynecologists or primary care providers from all US regions were identified from local association directories and an in-house database and were invited to participate in a...
Conclusion: US health care providers reported prescribing therapies for menopausal symptoms and noted that these therapies were perceived as generally effective; however, barriers to initiation of prescription therapy exist, and new treatment options are needed.
The effects of self-care education based on the health literacy index on self-care and quality of life among menopausal women: a randomized clinical trial - BMC Women's Health
Source : https://bmcwomenshealth.biomedcentral.com/articles/10.1186/s12905-022-02007-2
Purpose Aging is associated with many different health-related challenges for women such as menopause and its associated problems. Self-care (SC) is a factor with potential effects on menopause and its...
Conclusion: HLI-based SC education is effective in significantly improving menopausal women’s QOL and SC and can be used to improve health-related outcomes among menopausal women.
Genetic evidence for causal relationships between age at natural menopause and the risk of ageing-associated adverse health outcomes - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36409989/
Our study confirms that the decline in bone density with menopause causally translates into fractures and osteoporosis. Additionally, this is the first causal epidemiological analysis to our knowledge to find...
Conclusion: Our study confirms that the decline in bone density with menopause causally translates into fractures and osteoporosis. Additionally, this is the first causal epidemiological analysis to our knowledge to find an increased risk of lung cancer with increasing ANM. This finding is consistent with molecular and epidemiological studies...
Cognitive decline and dementia in women after menopause: Prevention strategies
Source : https://www.maturitas.org/article/S0378-5122(22)00235-3/fulltext
Cognitive decline (CD) and dementia constitute a public health problem worldwide. The associations between the length of the reproductive period, the onset of menopause, and neurogenerative disorders have been well...
Discussion: There is currently no biomarker of cognitive decline and no prophylactic treatment. Even though a growing amount of data is supporting lifestyle and nutritional modification to control the possible onset of cognitive decline, primary prevention strategies dedicated to the postmenopausal group of the population are still lacking....
Conclusion: These findings suggest that systemically administered HT before and during menopause is associated with higher risk of depression, especially in the years immediately after initiation, whereas locally administered HT is associated with lower risk of depression for women 54 years or older.
Conclusion: In this randomized clinical trial, 8-wk combined treatment with PFMT EA led to a greater improvement in SUI symptoms and better outcomes than with PFMT sham EA.
Can precision medicine get us through menopause?
Source : https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00544-8/fulltext
Women spend up to three decades in the post-menopausal phase of life, which is often accompanied by a wide variety of life-disrupting symptoms, including vasomotor symptoms, sleep disturbances, cognitive decline,...
Discussion: Using the comprehensive broad database generated, statistical mediation analyses were performed to lend insight into mechanisms driving the observed changes. These analyses revealed some novel and potentially important associations between diet, gut microbial changes, and health indicators.
Conclusion: In this secondary analysis of a randomized clinical trial, a significant, although small, increase in serum estradiol levels was noted after 12 weeks of vaginal estrogen administration. The clinical relevance of this small increase is uncertain.
-
Menopause Connect3yrKey Points • Source: JAMA Network Open • Meaning: “Low-dose vaginal estradiol use was associated with a small increase in serum estradiol concentrations of uncertain clinical significance.” • In the current secondary analysis of randomized clinical Show More
Lactobacilli and Cytokine Modifications during Menopause and Their Relation to Vulvar and Vulvovaginal Disorders
Source : https://e-jmm.org/DOIx.php?id=10.6118/jmm.22001
Lactobacilli and Cytokine Modifications during Menopause and Their Relation to Vulvar and Vulvovaginal Disorders Kushal Gandhi,Nathan Joshua Manales,John Garza,Samuel David,Asley Sanchez, 1 1 1 3 1 and Gary Ventolini 1...
Conclusion: The levels of vaginal cytokine and Lactobacillus profile were significantly different between the pre-menopausal and post-menopausal groups.
"Let's see what happens:"-Women's experiences of open-label placebo treatment for menopausal hot flushes in a randomized controlled trial
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0276499
Open-label (honestly prescribed) placebos are an ethical way to evoke placebo effects in patients. As part of a mixed-methods study, we conducted in-depth interviews with eight menopausal women who underwent...
Discussion: The patient interviews with menopausal women who benefitted from OLP treatment as part of an RCT indicate that placebos administered without deception and embedded in a clinical context can elicit salubrious benefits. Participants noted that they had an initially positive, curious, and “couldn’t hurt” attitude towards...
Hormone replacement therapy prescribing in menopausal women in the UK: a descriptive study
Source : https://bjgpopen.org/content/early/2022/10/31/BJGPO.2022.0126
Background Recent studies on the prescribing of hormone replacement therapy (HRT) medicines to treat symptoms of menopause are lacking. Aim To describe the prescribing of HRT in a cohort of...
Conclusion: This study shows a steady increase in the number of women receiving their first prescription for HRT during the study period, which suggests regained acceptance of HRT medicines.