Phosphorylated proteomics-based analysis of the effects of semaglutide on hippocampi of high-fat diet-induced-obese mice - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36998046/
The aim of this paper was to investigate the effects of semaglutide on phosphorylated protein expression, and its neuroprotective mechanism in hippocampi of high-fat-diet-induced obese mice. In total, 16 obese...
Conclusions/Relevance: This study demonstrates for the first time that semaglutide exerts neuroprotective effects by reducing HTT Ser1843, NEFH Ser 661 phosphorylation and increasing NEFL Ser 473 phosphorylation in hippocampal tissue of obese mice.
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This is used for those patients with obesity and they have an ample weight loss as experience from the weekly use of the product
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Once-Weekly Semaglutide in Adolescents with Obesity - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36322838/
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Relevance: We were impressed that at week 68 the difference between the semaglutide group and the placebo group in the change in body-mass index was −16.7 percentage points and in body weight was −17.4 percentage points.
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Semaglutide 2·4 mg once weekly in patients with non-alcoholic steatohepatitis-related cirrhosis: a randomised, placebo-controlled phase 2 trial
Source : https://www.thelancet.com/journals/langas/article/PIIS2468-1253(23)00068-7/fulltext
Patients with non-alcoholic steatohepatitis (NASH)-related cirrhosis are at particularly high risk of developing potentially life-threatening liver-related morbidities, such as portal hypertension, hepatic decompensation, hepatocellular carcinoma, liver-related mortality, and cardiovascular events.,...
Interpretation: In patients with NASH and compensated cirrhosis, semaglutide did not significantly improve fibrosis or achievement of NASH resolution versus placebo. No new safety concerns were raised.
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Weight loss breaks the bond between nonalcoholic fatty liver disease and cardiovascular diseases: A clinical and epidemiological perspective - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36951144/
Nonalcoholic fatty liver disease (NAFLD) is a growing health concern that is closely related to obesity and metabolic syndrome. In particular, NAFLD has been increasingly reported in adolescents and young...
Conclusions/Relevance: Besides the widespread use of bariatric surgery, the development of new GLP-1 agonists and GLP-1 GIP agonists revolutionized the treatment of obesity in recent years. Here, we discuss the interwoven correlation between obesity, NAFLD, and CVD and the benefits of weight-lowering approaches.
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